J Gastroenterol:日本的诊断标准可以在某些患者发展为慢性胰腺炎之前对其进行识别

2020-09-26 MedSci原创 MedSci原创

慢性胰腺炎(CP)是一种胰腺纤维性炎症疾病。在CP尚未确立和不可逆转之前,早期诊断和干预对改善长期疗效至关重要。2009年日本提出了世界上第一个早期CP的诊断标准,但其临床实用性仍难以确定。一项多中心

慢性胰腺炎(CP)是一种胰腺纤维性炎症疾病。在CP尚未确立和不可逆转之前,早期诊断和干预对改善长期疗效至关重要。2009年日本提出了世界上第一个早期CP的诊断标准,但其临床实用性仍难以确定。一项多中心、前瞻性的研究旨在明确早期CP患者是否会进展为明确的CP,研究结果已在线发表于J Gastroenterol

前瞻性地随访根据日本诊断标准诊断为早期CP的患者2年。分析患者的临床资料,包括症状、饮酒和吸烟状态、实验室数据、影像学检查结果和治疗方法。

 

结果显示,在83名完成2年随访的患者中,4名(4.8%)患者发展为CP。48名(57.8%)患者的诊断没有变化,31名(37.3%)患者的诊断降级。4例进展期患者均为男性,喝酒及吸烟者(3例为现在,1例为曾经),且持续饮酒。对比进展组(n=4)和非进展组(n=79)的临床资料发现,病因(酒精相关)、吸烟状态和是否有急性胰腺炎发作与进展为明确的CP有关。

综上所述,该研究结果表明,日本的诊断标准可以在某些患者发展为明确的CP之前对其进行识别,而大多数患者没有进展。

 

原始出处:

 

Atsushi MasamuneTatsuhide Nabeshima, et al., Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria. J Gastroenterol. 2019 Oct;54(10):928-935. doi: 10.1007/s00535-019-01602-9.

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