Nat Genet:前列腺癌转移过程重新激活发育表观基因组程序

2020-08-08 AlexYang MedSci原创

表观遗传过程能够控制前列腺癌(PCa)生物学,可由PCa细胞对雄激素受体(AR)(一个前列腺主调控转录因子)的依赖来证实。

表观遗传过程能够控制前列腺癌(PCa)生物学,可由PCa细胞对雄激素受体(AR)(一个前列腺主调控转录因子)的依赖来证实。

研究包含的样本情况

最近,有研究人员从人类组织样本中生成了268个表观基因组数据集,用来扫描两种状态的转换过程,即从正常前列腺上皮细胞到局部PCa的转变,再到转移的转变。研究结果发现,转移PCa中的重编程AR并不是从头创建的,而是由转录因子FOXA1和HOXB13在正常前列腺癌上皮中预先植入的。转移疾病中重编程的调控元件能够阻止潜在的发育程序,并涉及了与前列腺器官发生的有关位点。对重新激活的调控元件的分析鉴定和功能验证了之前未知的HOXB13、FOXA1和NKX3-1转移特异性增强子。另外,研究人员还发现了前列腺特异性调控元件与PCa风险的遗传和体细胞变异强度强烈相关。

功能相关的mCRPC增强子鉴定

最后,研究人员指出,通过表观基因组调查前列腺生物学是理解肿瘤恶化机制的基础。

原始出处:

Mark M. Pomerantz, Xintao Qiu, Yanyun Zhu et al. Prostate cancer reactivates developmental epigenomic programs during metastatic progression. Nat Genet. 20 July 2020

 

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    2021-06-05 cy0324
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    2021-05-14 liye789132251
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  5. 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  6. 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  7. 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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040804, encodeId=bb891040804d1, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Aug 08 17:44:33 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
    2020-08-10 neurowu
  9. 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    2020-08-08 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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