Aging Cell:老年人伤口愈合为何更困难?

2021-04-15 haibei MedSci原创

在这项概念验证研究中,研究人员使用双活检实验设计,在24名健康受试者中调查了人类伤口愈合过程中p16、p21和其他衰老相关生物标志物的表达。

已有的研究显示,人类皮肤伤口的愈合会经历四个阶段:血小板激活启动了凝血稳态级联;以中性粒细胞、淋巴细胞和巨噬细胞涌入为特征的炎症反应随之而来,并持续2-3天;在接下来的2-4周内,细胞增殖和肉芽组织的形成封闭了受损区域;最后,重塑和疤痕形成持续数月,以完成愈合过程。

人们已经观察到,老年人的伤口愈合过程受损,然而,随着年龄的增长,钝化伤口愈合的分子机制尚未被确定。在小鼠模型中的研究表明,细胞衰老对伤口愈合很重要。细胞衰老和衰老相关分泌表型(SASP)对皮肤伤口愈合有积极作用。消除p16阳性衰老细胞可延缓伤口愈合,表明它们对伤口愈合过程有积极的贡献。同样的机制是否参与人类伤口愈合还没有被评估。

最近,研究人员设计了一项试验性研究,以探究衰老生物标志物在健康的年轻和老年人类皮肤伤口中的表达。在这项概念验证研究中,研究人员使用双活检实验设计,在24名健康受试者中调查了人类伤口愈合过程中p16、p21和其他衰老相关生物标志物的表达。第一次打孔活检创造了伤口并建立了基线。第二次活检,与第一次活检同心,并在伤口后几天采取,用于通过免疫组织化学和RNA FISH的实验手段探查生物标志物的表达。

为了评估年龄的影响,研究人员招募了12名性别匹配的年轻(30.2±1.3岁)和12名性别匹配的老年(75.6±1.8岁)受试者。研究人员发现,p21和p53,而不是p16,在年轻的受试者的愈合过程中被诱导,但不是老年人。

在基线和受伤的正常皮肤中p16,p21和p53蛋白表达情况

从HES1的诱导性激活推断出Notch信号在p21表达中的作用。此外,其他SASP生物标志物如二肽基肽酶-4(DPP4)在年轻组和年长组伤口时均被显著诱导,而基质金属肽酶9(MMP9)仅在年轻组被诱导。衰老相关的β-半乳糖苷酶(SA-β-gal)在伤口前后均未检测到。

总之,这项试验研究表明,人类皮肤伤口愈合的特点可能是年轻和年长者之间p21和p53的表达有差异。

 

原始出处:

Chee W. Chia et al. Age‐associated expression of p21and p53 during human wound healing. Aging Cell (2021). 

 

 

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    2021-10-13 维他命
  3. [GetPortalCommentsPageByObjectIdResponse(id=1872191, encodeId=4f4a18e219155, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Jan 05 09:32:48 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962500, encodeId=665e1962500a7, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Oct 13 08:32:48 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=966416, encodeId=909196641601, content=老了,啥都难, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ecf2148817, createdName=13820079eem, createdTime=Mon May 17 22:27:23 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957290, encodeId=a5e295e29031, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/a7082efd72134f339011deffae56d660/9f9bdab2a00341ce92bf6fd196c67f81.png, createdBy=4e205474392, createdName=七安, createdTime=Thu Apr 15 14:52:38 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958331, encodeId=8463958331fe, content=taught, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:26:21 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958330, encodeId=9536958330a8, content=老年人 血管都不好 营养差 糖尿病等影响各种恢复, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:26:17 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309912, encodeId=310713099125e, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Apr 16 22:32:48 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957245, encodeId=8b5295e2456b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49a11912866, createdName=ms9852187465738680, createdTime=Thu Apr 15 12:02:32 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-05-17 13820079eem

    老了,啥都难

    0

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    2021-04-15 七安

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

    0

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    2021-04-19 ZJYYY7

    taught

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1872191, encodeId=4f4a18e219155, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Jan 05 09:32:48 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962500, encodeId=665e1962500a7, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Oct 13 08:32:48 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=966416, encodeId=909196641601, content=老了,啥都难, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ecf2148817, createdName=13820079eem, createdTime=Mon May 17 22:27:23 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957290, encodeId=a5e295e29031, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/a7082efd72134f339011deffae56d660/9f9bdab2a00341ce92bf6fd196c67f81.png, createdBy=4e205474392, createdName=七安, createdTime=Thu Apr 15 14:52:38 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958331, encodeId=8463958331fe, content=taught, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:26:21 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958330, encodeId=9536958330a8, content=老年人 血管都不好 营养差 糖尿病等影响各种恢复, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:26:17 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309912, encodeId=310713099125e, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Apr 16 22:32:48 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957245, encodeId=8b5295e2456b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49a11912866, createdName=ms9852187465738680, createdTime=Thu Apr 15 12:02:32 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-19 ZJYYY7

    老年人 血管都不好 营养差 糖尿病等影响各种恢复

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    2021-04-15 ms9852187465738680

    学习了

    0

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