Anesth Analg:心脏手术患者低潮气量通气与氧合改善相关

2020-01-28 anesthGH “罂粟花”微信号

较低的潮气量与心脏手术患者术后氧合的改善相关。

背景与目的

低潮气量机械通气对非心脏手术的患者有好处;然而它是否对心脏手术的患者有好处目前不清楚。

方  法

我们回顾性研究了2010年1月至2016年8月中旬接受单腔气管插管机械通气的需要通过胸骨正中切口进行体外循环的择期心脏手术患者。分析体外循环手术期间的时间加权平均潮气量(毫升/千克预计体重[PBW])。检查潮气量与术后氧合(动脉血氧分压(PaO2)/吸入氧分数[PaO2/FiO2])、氧合受损(PaO2/FiO2<300)和临床结局的关系。

结 果

在9359名心脏手术患者中,潮气量较大与术后氧合稍差有关。术后潮气量每增加1mL/kg PBW,PaO2/FiO2下降1.05%(97.5%可信区间[CI],?1.74至?0.37;P=0.0005)。术中潮气量的增加还与氧合受损的几率增加有关(优势比[OR;97.5%CI]:每1mL/kg PBW增加1.08[1.02-1.14];P=0.0029),插管时间稍长(每1mL/kg潮气量增加5%)(危险比[98.33%CI],每1mL/kg PBW 0.95[0.93-0.98];P<0.0001),死亡率增加(OR[98.33%CI],每增加1mL/kg PBW,1.34[1.06-1.70];P=0.0144)。术中潮气量增加也与术后急性呼吸衰竭有关(OR[98.33%CI],每增加1mL/kg PBW 1.16[1.03-1.32];P=0.0146),但与其他肺部并发症无关。

结 论

较低的潮气量与心脏手术患者术后氧合的改善相关。

原始出处:

Jia Y,  Leung SM,  Turan A;Low Tidal Volumes Are Associated With Slightly Improved Oxygenation in Patients Having Cardiac Surgery: A Cohort Analysis;Anesth. Analg. 2020 Jan 02;PMID:31904632;DOI:10.1213/ANE.0000000000004608

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    2020-12-17 经常头晕
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    2020-08-15 AspirantSuo
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