Obstet Gynecol:子宫内膜异位症与不良妊娠结局的风险

2019-08-28 xing.T MedSci原创

由此可见,腹腔镜确诊的子宫内膜异位症与几种不良妊娠结局之间存在关联。未来的研究应侧重于这些关系的潜在生物学机制,以便为筛查或预防性干预提供信息。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一研究文章,研究人员旨在调查子宫内膜异位症与不良妊娠结局之间的关系。 

在1989年,护士健康研究II中年龄在25岁至42岁之间的女性(n=116429)报告了基线时和之后每2年一次妊娠和生殖健康的详细信息。在2009年,他们完成了一份详细的、以妊娠为重点的调查问卷。该研究中共报告了196722次妊娠。不良妊娠结局包括自然流产、异位妊娠、死胎、妊娠期糖尿病(GDM)、妊娠期高血压疾病(先兆子痫或妊娠期高血压)、早产和低出生体重。研究人员使用多变量对数二项式回归估计了有和没有腹腔镜确诊的子宫内膜异位病史的妇女不良妊娠结局的相对风险(RR)和95%CI,并使用广义估计方程来计算每名妇女的多胎妊娠。

子宫内膜异位症与更大的流产风险相关(自然流产:RR为1.40,95%CI为1.31-1.49;异位妊娠:RR为1.46,95%CI为1.19-1.80)。子宫内膜异位症也伴有更大的GDM(RR为1.35,95%CI为1.11-1.63)和妊娠期高血压疾病(RR为1.30,95%CI为1.16-1.45)风险。 

由此可见,腹腔镜确诊的子宫内膜异位症与几种不良妊娠结局之间存在关联。未来的研究应侧重于这些关系的潜在生物学机制,以便为筛查预防性干预提供信息。 

原始出处:

Farland, Leslie V. ScD,et al.Endometriosis and Risk of Adverse Pregnancy Outcomes.Obstetrics & Gynecology.2019.https://journals.lww.com/greenjournal/Fulltext/2019/09000/Endometriosis_and_Risk_of_Adverse_Pregnancy.14.aspx

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    2020-01-17 yhy100200
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