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ENDO 2016：relamorelin治疗神经性厌食症

2016-04-09 Mechront 译 MedSci原创

relamorelin神经性厌食症胃排空
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内分泌学会年会公布了胃饥饿素受体激动剂relamorelin治疗神经性厌食症的2期概念验证数据。为评估relamorelin对胃排空时间和体重的影响，以及该药物的安全性和耐受性，麻省综合医院神经内分泌的Anne Klibanski博士和同事进行了一项随机、双盲、安慰剂对照试验，纳入了22名神经性厌食症女性患者，随机分为每天一次100 µg relamorelin或安慰剂，共4周。数据显示，rela

内分泌学会年会公布了胃饥饿素受体激动剂relamorelin治疗神经性厌食症的2期概念验证数据。

为评估relamorelin对胃排空时间和体重的影响，以及该药物的安全性和耐受性，麻省综合医院神经内分泌的Anne Klibanski博士和同事进行了一项随机、双盲、安慰剂对照试验，纳入了22名神经性厌食症女性患者，随机分为每天一次100 µg relamorelin或安慰剂，共4周。

数据显示，relamorelin组与安慰剂组相比，患者的胃排空时间显著更短(P = .03)，体重增加更多（0.86 + 0.4 kg vs. 0.04 + 0.28 kg (P = .12)）。并且患者对relamorelin具有良好的耐受性。研究期间有2名患者因为饥饿感的不断增加，未能完成研究。

Anne Klibanski博士说：“relamorelin治疗神经性厌食症的首次临床试验结果表明该药物是十分有前途的，该药物可能是从以下两方面起作用：一是直接刺激饥饿感，而是让厌食症患者的胃排空正常化。在未来，将会对该药物治疗神经性厌食症的长期有效性和安全性进行研究。”

原始出处：

Fazeli P, et al. Short-term treatment with a ghrelin agonist significantly improves gastric emptying in anorexia nervosa. Presented at: The Endocrine Society Annual Meeting; April 1-4, 2016; Boston.

Relamorelin effective, safe for anorexia nervosa.Healio.April 8, 2016


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    2017-01-18 windight

    #relamorelin#

    0

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    2017-01-26 xuyu

    #神经性厌食#

    0

  3. 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    2017-03-03 lxg951

    #LAM#

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAEnLB9zphibTvdpE2miaXQ7yVricG3ibiamDVnkia62xuDia998/0, createdBy=98b91706957, createdName=Wechatdb9b98ec, createdTime=Sun Apr 10 02:03:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-04-28 listen318

    #神经性厌食症#

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78127, encodeId=4910e81278c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77479, encodeId=eb28e7479dd, content=学习了 长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAEnLB9zphibTvdpE2miaXQ7yVricG3ibiamDVnkia62xuDia998/0, createdBy=98b91706957, createdName=Wechatdb9b98ec, createdTime=Sun Apr 10 02:03:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-09-07 hywen7326

    #神经性#

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAEnLB9zphibTvdpE2miaXQ7yVricG3ibiamDVnkia62xuDia998/0, createdBy=98b91706957, createdName=Wechatdb9b98ec, createdTime=Sun Apr 10 02:03:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-04-14 李继凯

    高大上的文章

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAEnLB9zphibTvdpE2miaXQ7yVricG3ibiamDVnkia62xuDia998/0, createdBy=98b91706957, createdName=Wechatdb9b98ec, createdTime=Sun Apr 10 02:03:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-04-14 李继凯

    值得学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1958324, encodeId=f5b419583240e, content=<a href='/topic/show?id=bd221529205' target=_blank style='color:#2F92EE;'>#relamorelin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15292, encryptionId=bd221529205, topicName=relamorelin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jan 18 14:50:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049667, encodeId=b19b204966ecb, content=<a href='/topic/show?id=257ae42978d' target=_blank style='color:#2F92EE;'>#神经性厌食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74297, encryptionId=257ae42978d, topicName=神经性厌食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Thu Jan 26 20:50:00 CST 2017, time=2017-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057579, encodeId=89a0205e57964, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Fri Mar 03 20:50:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969804, encodeId=51911969804ea, content=<a href='/topic/show?id=0dabe4298a6' target=_blank style='color:#2F92EE;'>#神经性厌食症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74298, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78127, encodeId=4910e81278c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77479, encodeId=eb28e7479dd, content=学习了 长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Tue Apr 12 07:55:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440833, encodeId=d936144083353, content=<a href='/topic/show?id=ad2436984cf' target=_blank style='color:#2F92EE;'>#厌食症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36984, encryptionId=ad2436984cf, topicName=厌食症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ba4763359, createdName=12498a1cm68暂无昵称, createdTime=Mon Apr 11 02:50:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76635, encodeId=f52ce6635ad, content=临床中很多这样的患者，, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAEnLB9zphibTvdpE2miaXQ7yVricG3ibiamDVnkia62xuDia998/0, createdBy=98b91706957, createdName=Wechatdb9b98ec, createdTime=Sun Apr 10 02:03:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-04-12 hekzn

    学习了 长知识

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1958324, encodeId=f5b419583240e, content=<a href='/topic/show?id=bd221529205' target=_blank style='color:#2F92EE;'>#relamorelin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15292, encryptionId=bd221529205, topicName=relamorelin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jan 18 14:50:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049667, encodeId=b19b204966ecb, content=<a href='/topic/show?id=257ae42978d' target=_blank style='color:#2F92EE;'>#神经性厌食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74297, encryptionId=257ae42978d, topicName=神经性厌食)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78127, encodeId=4910e81278c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77479, encodeId=eb28e7479dd, content=学习了 长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Tue Apr 12 07:55:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440833, encodeId=d936144083353, content=<a href='/topic/show?id=ad2436984cf' target=_blank style='color:#2F92EE;'>#厌食症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36984, encryptionId=ad2436984cf, topicName=厌食症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ba4763359, createdName=12498a1cm68暂无昵称, createdTime=Mon Apr 11 02:50:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76635, encodeId=f52ce6635ad, content=临床中很多这样的患者，, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAEnLB9zphibTvdpE2miaXQ7yVricG3ibiamDVnkia62xuDia998/0, createdBy=98b91706957, createdName=Wechatdb9b98ec, createdTime=Sun Apr 10 02:03:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-04-11 12498a1cm68暂无昵称

    #厌食症#

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78127, encodeId=4910e81278c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:33:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77479, encodeId=eb28e7479dd, content=学习了 长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Tue Apr 12 07:55:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440833, encodeId=d936144083353, content=<a href='/topic/show?id=ad2436984cf' target=_blank style='color:#2F92EE;'>#厌食症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36984, encryptionId=ad2436984cf, topicName=厌食症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c0ba4763359, createdName=12498a1cm68暂无昵称, createdTime=Mon Apr 11 02:50:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76635, encodeId=f52ce6635ad, content=临床中很多这样的患者，, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAEnLB9zphibTvdpE2miaXQ7yVricG3ibiamDVnkia62xuDia998/0, createdBy=98b91706957, createdName=Wechatdb9b98ec, createdTime=Sun Apr 10 02:03:00 CST 2016, time=2016-04-10, status=1, ipAttribution=)]
    2016-04-10 Wechatdb9b98ec

    临床中很多这样的患者，

    0

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