J INTERN MED:维生素D、呼吸道感染和慢性病之间的关系

2021-09-22 MedSci原创 MedSci原创

补充维生素D对呼吸道感染和慢性疾病的影响,目前来自RCT和RCT荟萃分析的证据并不一致。最有可能受益的人是那些基线维生素D缺乏或患有特定高风险疾病的个体。

观察性研究表明,维生素D缺乏症(VDD)与呼吸道感染、骨骼健康受损和多数慢性病有关。

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,研究人员旨在评估补充维生素D与降低这些疾病风险之间的潜在的因果关系,并对随机对照试验(RCT)和针对RCT的现有荟萃分析的证据进行了审查。

研究人员检索了PubMed、Embase、Cochrane Library和Web of Science数据库,检索时间从其成立至2021年3月。研究人员仅纳入了重点关注维生素D与呼吸系统疾病、骨骼健康、血管疾病、糖尿病和癌症之间相关性的RCT和这些RCT进行的荟萃分析。

研究人员共纳入107项随机对照试验和62项随机对照试验进行的荟萃分析。尽管大多数RCT并未支持补充维生素D具有益处,但在VDD和急性呼吸道感染、住院老人的骨折、伴有糖尿病前期患者的2型糖尿病和癌症死亡较高风险的人群中伴有益处的证据。相比之下,没有发现补充维生素D对其他呼吸系统疾病、社区成人骨折、跌倒、癌症发病率或心血管疾病具有令人信服的有益证据。

由此可见,补充维生素D对呼吸道感染和慢性疾病的影响,目前来自RCT和RCT荟萃分析的证据并不一致。最有可能受益的人是那些基线维生素D缺乏或患有特定高风险疾病的个体。需要采取公共卫生举措在全球范围内消除VDD,未来的研究将通过“精确预防”方法来加强,以确定最有可能从补充维生素D中受益的人群。

原始出处:

Davaasambuu Ganmaa.et al.Vitamin D, respiratory infections, and chronic disease: Review of meta-analyses and randomized clinical trials.J INTERN MED.2021.https://doi.org/10.1111/joim.13399

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    2021-09-24 随梦飞扬

    维生素D缺乏症(VDD)与呼吸道感染、骨骼健康受损和多数慢性病有关

    0

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    2021-09-24 qjddjq
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    2021-09-24 zhmscau
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1054461, encodeId=3c85105446141, content=维生素D缺乏症(VDD)与呼吸道感染、骨骼健康受损和多数慢性病有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Sep 24 15:01:09 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264075, encodeId=3e1812640e5b2, content=<a href='/topic/show?id=847353580bf' target=_blank style='color:#2F92EE;'>#慢性病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53580, encryptionId=847353580bf, topicName=慢性病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282563, encodeId=e5881282563ba, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611262, encodeId=0715161126243, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054049, encodeId=55c4105404923, content=涨知识了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210323/9e19622684d0495ab64e9c2d9662c072/5dbfd70bbbc341839babfa759db3f40b.jpg, createdBy=d8d72465758, createdName=12428a36m61暂无昵称, createdTime=Thu Sep 23 08:54:06 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054034, encodeId=394b1054034d4, content=???, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210908/c56681ddc31c4bd4a5911801095fdf8a/fd23b96ae1244b55a3bd7f6d6a79d0e7.jpg, createdBy=56e15596007, createdName=ms6000001253705830, createdTime=Thu Sep 23 08:26:48 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054021, encodeId=21ca105402181, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:06:21 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053915, encodeId=2e8f1053915c1, content=真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/ae7665075c184c23a6e784e6269320b0/c581d11218024bf1af694b1df0036472.jpg, createdBy=75095431701, createdName=ms5000000050796128, createdTime=Wed Sep 22 21:03:28 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-23 12428a36m61暂无昵称

    涨知识了啊

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1054461, encodeId=3c85105446141, content=维生素D缺乏症(VDD)与呼吸道感染、骨骼健康受损和多数慢性病有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Sep 24 15:01:09 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264075, encodeId=3e1812640e5b2, content=<a href='/topic/show?id=847353580bf' target=_blank style='color:#2F92EE;'>#慢性病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53580, encryptionId=847353580bf, topicName=慢性病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282563, encodeId=e5881282563ba, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611262, encodeId=0715161126243, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054049, encodeId=55c4105404923, content=涨知识了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210323/9e19622684d0495ab64e9c2d9662c072/5dbfd70bbbc341839babfa759db3f40b.jpg, createdBy=d8d72465758, createdName=12428a36m61暂无昵称, createdTime=Thu Sep 23 08:54:06 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054034, encodeId=394b1054034d4, content=???, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210908/c56681ddc31c4bd4a5911801095fdf8a/fd23b96ae1244b55a3bd7f6d6a79d0e7.jpg, createdBy=56e15596007, createdName=ms6000001253705830, createdTime=Thu Sep 23 08:26:48 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054021, encodeId=21ca105402181, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:06:21 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053915, encodeId=2e8f1053915c1, content=真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/ae7665075c184c23a6e784e6269320b0/c581d11218024bf1af694b1df0036472.jpg, createdBy=75095431701, createdName=ms5000000050796128, createdTime=Wed Sep 22 21:03:28 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-23 ms6000001253705830

    ???

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1054461, encodeId=3c85105446141, content=维生素D缺乏症(VDD)与呼吸道感染、骨骼健康受损和多数慢性病有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Sep 24 15:01:09 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264075, encodeId=3e1812640e5b2, content=<a href='/topic/show?id=847353580bf' target=_blank style='color:#2F92EE;'>#慢性病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53580, encryptionId=847353580bf, topicName=慢性病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282563, encodeId=e5881282563ba, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611262, encodeId=0715161126243, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054049, encodeId=55c4105404923, content=涨知识了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210323/9e19622684d0495ab64e9c2d9662c072/5dbfd70bbbc341839babfa759db3f40b.jpg, createdBy=d8d72465758, createdName=12428a36m61暂无昵称, createdTime=Thu Sep 23 08:54:06 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054034, encodeId=394b1054034d4, content=???, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210908/c56681ddc31c4bd4a5911801095fdf8a/fd23b96ae1244b55a3bd7f6d6a79d0e7.jpg, createdBy=56e15596007, createdName=ms6000001253705830, createdTime=Thu Sep 23 08:26:48 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054021, encodeId=21ca105402181, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:06:21 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053915, encodeId=2e8f1053915c1, content=真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/ae7665075c184c23a6e784e6269320b0/c581d11218024bf1af694b1df0036472.jpg, createdBy=75095431701, createdName=ms5000000050796128, createdTime=Wed Sep 22 21:03:28 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-23 仁术2021

    不错,学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1054461, encodeId=3c85105446141, content=维生素D缺乏症(VDD)与呼吸道感染、骨骼健康受损和多数慢性病有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Sep 24 15:01:09 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264075, encodeId=3e1812640e5b2, content=<a href='/topic/show?id=847353580bf' target=_blank style='color:#2F92EE;'>#慢性病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53580, encryptionId=847353580bf, topicName=慢性病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282563, encodeId=e5881282563ba, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611262, encodeId=0715161126243, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Sep 24 11:46:15 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054049, encodeId=55c4105404923, content=涨知识了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210323/9e19622684d0495ab64e9c2d9662c072/5dbfd70bbbc341839babfa759db3f40b.jpg, createdBy=d8d72465758, createdName=12428a36m61暂无昵称, createdTime=Thu Sep 23 08:54:06 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054034, encodeId=394b1054034d4, content=???, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210908/c56681ddc31c4bd4a5911801095fdf8a/fd23b96ae1244b55a3bd7f6d6a79d0e7.jpg, createdBy=56e15596007, createdName=ms6000001253705830, createdTime=Thu Sep 23 08:26:48 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054021, encodeId=21ca105402181, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:06:21 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053915, encodeId=2e8f1053915c1, content=真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/ae7665075c184c23a6e784e6269320b0/c581d11218024bf1af694b1df0036472.jpg, createdBy=75095431701, createdName=ms5000000050796128, createdTime=Wed Sep 22 21:03:28 CST 2021, time=2021-09-22, status=1, ipAttribution=)]
    2021-09-22 ms5000000050796128

    真好

    0

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