JNNP:感染COVID-19的脑卒中患者的特点和预后:一项英国多中心病例对照研究

2020-11-27 MedSci原创 MedSci原创

COVID-19-是一种病毒性肺炎,其特征是干咳、高烧、呼吸急促、味觉和嗅觉丧失。然而,引起这种疾病的病毒SARS-CoV-2可能会影响缺血性中风的发生。虽然这个结论还存在争议。本文目的是探讨脑卒中的

COVID-19-是一种病毒性肺炎,其特征是干咳、高烧、呼吸急促、味觉和嗅觉丧失。然而,引起这种疾病的病毒SARS-CoV-2可能会影响缺血性中风的发生。虽然这个结论还存在争议。本文目的是探讨脑卒中的哪些特征和预后与COVID-19病毒相关。

方法:研究包括2020年3月9日至7月5日在英格兰和苏格兰13家医院住院的脑卒中患者。收集了86例中风(81例缺血性中风和5例脑出血)患者在中风发作时感染COVID-19的临床数据。他们与同期收治的1384例中风(1193例缺血性中风和191例脑出血)进行了比较,这些患者没有感染COVID-19的证据(对照组)。另外37名中风后出现COVID-19的患者在内的所有中风入院患者都被纳入两个logistic回归分析,研究哪些临床特征与COVID-19状态和住院患者死亡率独立相关。

结果:亚洲人缺血性脑卒中发生率高于缺血性对照组(18.8%比6.7%,p<0.0002),多发性大血管闭塞发生率高(17.9%比8.1%,p<0.03),严重程度更高(美国国立卫生研究院卒中量表评分中位数8分对5分,p<0.002),与较高的D-二聚体水平相关(p<0.01),与出院时更严重的残疾(改良Rankin评分中位数4比3,p<0.0001)和住院病人死亡(19.8%比6.9%,p<0.0001)相关。病人入院时中风复发在病例组和对照组中很少见(2.3%比1.0%,NS)。

结论:COVID-19可能是急性缺血性脑卒中发病、特点和预后的重要调节因素。

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    2021-03-19 amyloid
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    2021-07-28 xugc
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    2020-11-28 Baodongxu

    之前有研究说新冠诱发心脏病风险被高估,不知道卒中方面未来会朝什么方向发展

    0

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    2020-11-28 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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