NEJM:连续三轮大规模阿奇霉素给药防控雅司病!

2022-01-07 xiaozeng MedSci原创

以6个月为间隔进行三轮阿奇霉素大规模给药后雅司病社区患病率的降低幅度大于一轮阿奇霉素大规模给药后进行两轮靶向治疗

雅司病又称热带莓疮,是由雅司螺旋体引起的一种慢性接触性传染病,主要流行于一些热带的农村地区,多发生于儿童与青少年。我国的广东、福建、广西、台湾等地曾偶有散发病例。

雅司螺旋体,亦称纤细螺旋体,形态似梅毒螺旋体,体长10~13μm,螺旋紧密,能活泼运动,在体外不能生长,于特殊培养基中能存活数日而不能增殖。能在~70℃干冰低温存毒力多年。

《新英格兰》近日发表了一项开放标签、整群随机、基于社区的临床试验的研究结果。在该试验中,研究人员将38个病房随机分成两组(各19个),对照组接受一轮阿奇霉素集体给药,然后是两轮针对活跃病例的靶向治疗;实验组接受三轮阿奇霉素集体给药。三轮给药分别是在基线、第6个月和第12个月。主要终点是雅司病活动病例的发生率。

对照组和实验组雅司病活动病例的发生率

对照组和实验组分别涵盖了30438位和26238位受试者。对照组共注射了24848剂阿奇霉素,实验组注射了59852剂阿奇霉素。第18个月时,对照组雅司病活动病例的发生率从基线时的0.46%降到了0.16%,而实验组从基线时的0.43%降到了0.04%(相对校正风险为 4.08, 95% CI 1.90-8.76)。

其他感染性溃疡的患病率在两个治疗组中下降的程度相似。18个月时,潜伏性雅司病在对照组994位儿童中的发生率为6.54%,在实验组945位儿童中的发生率为3.28%(相对校正风险 2.03, 95% CI 1.12-3.70)。在实验组中发现3例对大环内酯类耐药的雅司病。

综上,以6个月为间隔进行三轮阿奇霉素大规模给药后雅司病社区患病率的降低幅度大于一轮阿奇霉素大规模给药后进行两轮靶向治疗

原始出处:

John Lucy N,Beiras Camila G,Houinei Wendy et al. Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication.[J] .N Engl J Med, 2022, 386: 47-56.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2043475, encodeId=835b20434e5aa, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Fri Jun 10 13:08:32 CST 2022, time=2022-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182428, encodeId=0d59118242847, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbcd5675699, createdName=moyanju2796, createdTime=Sun Jan 09 07:24:05 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182359, encodeId=1d6f118235922, content=<a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210717/d2cb4857e66b463b9f7e61b63bbf19ea/95f23f544c0c40a7b9fc5cea7816f727.jpg, createdBy=140f1737581, createdName=lotus~, createdTime=Sat Jan 08 21:53:01 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182253, encodeId=4036118225315, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sat Jan 08 16:31:25 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182072, encodeId=20e011820e27a, content=目录Tom the first day of the year and, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c432136635, createdName=1861fdfa91m, createdTime=Sat Jan 08 06:54:35 CST 2022, time=2022-01-08, status=1, ipAttribution=)]
    2022-06-10 ylz8403
  2. [GetPortalCommentsPageByObjectIdResponse(id=2043475, encodeId=835b20434e5aa, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Fri Jun 10 13:08:32 CST 2022, time=2022-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182428, encodeId=0d59118242847, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbcd5675699, createdName=moyanju2796, createdTime=Sun Jan 09 07:24:05 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182359, encodeId=1d6f118235922, content=<a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210717/d2cb4857e66b463b9f7e61b63bbf19ea/95f23f544c0c40a7b9fc5cea7816f727.jpg, createdBy=140f1737581, createdName=lotus~, createdTime=Sat Jan 08 21:53:01 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182253, encodeId=4036118225315, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sat Jan 08 16:31:25 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182072, encodeId=20e011820e27a, content=目录Tom the first day of the year and, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c432136635, createdName=1861fdfa91m, createdTime=Sat Jan 08 06:54:35 CST 2022, time=2022-01-08, status=1, ipAttribution=)]
    2022-01-09 moyanju2796

    学习。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2043475, encodeId=835b20434e5aa, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Fri Jun 10 13:08:32 CST 2022, time=2022-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182428, encodeId=0d59118242847, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbcd5675699, createdName=moyanju2796, createdTime=Sun Jan 09 07:24:05 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182359, encodeId=1d6f118235922, content=<a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210717/d2cb4857e66b463b9f7e61b63bbf19ea/95f23f544c0c40a7b9fc5cea7816f727.jpg, createdBy=140f1737581, createdName=lotus~, createdTime=Sat Jan 08 21:53:01 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182253, encodeId=4036118225315, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sat Jan 08 16:31:25 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182072, encodeId=20e011820e27a, content=目录Tom the first day of the year and, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c432136635, createdName=1861fdfa91m, createdTime=Sat Jan 08 06:54:35 CST 2022, time=2022-01-08, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2043475, encodeId=835b20434e5aa, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Fri Jun 10 13:08:32 CST 2022, time=2022-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182428, encodeId=0d59118242847, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbcd5675699, createdName=moyanju2796, createdTime=Sun Jan 09 07:24:05 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182359, encodeId=1d6f118235922, content=<a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210717/d2cb4857e66b463b9f7e61b63bbf19ea/95f23f544c0c40a7b9fc5cea7816f727.jpg, createdBy=140f1737581, createdName=lotus~, createdTime=Sat Jan 08 21:53:01 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182253, encodeId=4036118225315, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sat Jan 08 16:31:25 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182072, encodeId=20e011820e27a, content=目录Tom the first day of the year and, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c432136635, createdName=1861fdfa91m, createdTime=Sat Jan 08 06:54:35 CST 2022, time=2022-01-08, status=1, ipAttribution=)]
    2022-01-08 屋顶瞄爱赏月

    好文章

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2043475, encodeId=835b20434e5aa, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Fri Jun 10 13:08:32 CST 2022, time=2022-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182428, encodeId=0d59118242847, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbcd5675699, createdName=moyanju2796, createdTime=Sun Jan 09 07:24:05 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182359, encodeId=1d6f118235922, content=<a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210717/d2cb4857e66b463b9f7e61b63bbf19ea/95f23f544c0c40a7b9fc5cea7816f727.jpg, createdBy=140f1737581, createdName=lotus~, createdTime=Sat Jan 08 21:53:01 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182253, encodeId=4036118225315, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sat Jan 08 16:31:25 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1182072, encodeId=20e011820e27a, content=目录Tom the first day of the year and, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c432136635, createdName=1861fdfa91m, createdTime=Sat Jan 08 06:54:35 CST 2022, time=2022-01-08, status=1, ipAttribution=)]
    2022-01-08 1861fdfa91m

    目录Tom the first day of the year and

    0

相关资讯

Clin Oral Investig:全身使用阿奇霉素作为III/IV期牙周炎患者洗牙和根管治疗的辅助治疗手段

长期以来,抗生素一直作为洗牙和根管治疗(SRP)标准治疗方案的辅助疗法。近日,发表于Clin Oral Investig的一项双盲随机平行臂安慰剂对照试验旨在确定阿奇霉素(AZI)作为洗牙和根管治疗(

CMI:单独使用羟氯喹或联合阿奇霉素对COVID-19患者死亡率的影响

羟氯喹联合或不联合阿奇霉素已被广泛用于治疗2019冠状病毒(COVID-19),此前对于早期的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)也具有体外抗病毒效果。

NEJM:多西环素治疗方案用于男男同性恋人群直肠衣原体感染

在直肠衣原体感染的男性同性恋人群中,7天的多西环素治疗方案在微生物学治愈率方面优于阿奇霉素方案

Thorax:阿奇霉素预防COPD急性加重的获益-危害分析

有急性加重史的COPD患者可能从阿奇霉素获益。

Lancet Respir Med:阿奇霉素能否让轻中度COVID-19患者获益?

研究评估了阿奇霉素能否有效降低正在门诊接受治疗的轻至中度COVID-19患者住院或死亡率。