Neurology:长期暴露于空气污染与老年人认知能力下降之间的关系

2020-04-09 MedSci原创 MedSci原创

居住在环境空气污染物水平较高地区的WHICAP参与者在入组时的认知得分较低,随着时间的推移,认知能力下降的速度较快。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,研究人员旨在探讨长期暴露于环境空气污染与城市老年人认知能力下降之间的关系。

该研究的数据来自于纽约市北部曼哈顿地区的2个前瞻性居民队列:华盛顿海茨-伍德伍德社区老龄化项目(WHICAP)和北部曼哈顿研究(NOMAS)。两个队列的参与者在招募时和随访期间都接受了全面的神经心理学测试。在每个队列中,研究人员使用逆概率加权线性混合模型来评估招募入组前一年平均住宅环境空气污染标志物(二氧化氮(NO2)、细颗粒物(PM2.5)和可吸入颗粒物(PM10))水平与整体和特定领域的认知指标之间的横向和纵向关联。

在5330名WHICAP参与者中,NO2的增加与入组时整体认知得分下降0.22个SD(95%置信区间[CI]为-0.30至-0.14)以及随访之间认知下降速度增快0.06个SD(95%置信区间为-0.08至-0.04)相关。PM2.5和PM10与不同功能认知领域的结果相似。研究人员在NOMAS中没有发现任何证据表明空气污染与的认知功能之间存在联系。

由此可见,居住在环境空气污染物水平较高地区的WHICAP参与者在入组时的认知得分较低,随着时间的推移,认知能力下降的速度较快。NOMAS是一个更小型的队列,重复测量次数更少,研究人员没有发现有统计学意义的相关性。这些结果为空气污染对认知退化和大脑健康存在不利影响提供了证据。

原始出处:

Erin R. Kulick,et al.Long-term exposure to air pollution and trajectories of cognitive decline among older adults.Neurology.2020.https://doi.org/10.1212/WNL.0000000000009314

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    2020-12-22 yinhl1978
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    2020-04-11 wxl882001

    了解一下

    0

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    2020-04-09 qingfengqishi5

    学习了,学习了

    0

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