NeuroImage:7T静息态功能磁共振成像研究觉醒和运动脑干核的功能连接体

2022-01-14 影像小生 MedSci原创

18个觉醒和运动脑干核的功能连接体与大脑的其他部分可能会提供更好的了解觉醒、睡眠和伴随的人类健康和疾病的运动功能。

脑干核在许多功能中发挥着关键作用,例如觉醒和运动控制。然而,由于传统成像的灵敏度和空间分辨率有限,以及缺乏这些大脑深层微小区域的图谱,在人类中,觉醒和运动脑干核的连接尚未得到充分研究。

为了全面了解睡眠、觉醒和相关运动过程,MartaBianciardi等在 20 名健康受试者中调查了18 个觉醒和运动脑干核的静息态功能连接。

A:所有觉醒和运动核的连接矩阵。B: 所有唤醒核和运动核的二维环形连接体。

该研究小组使用了高空间分辨率的 7 T 静息态 fMRI,以及最近开发的立体定向空间中这些核的体内概率图谱。此外,验证了脑干连接组方法对传统(例如 3T)功能磁共振成像的可译性。觉醒脑干核显示出高度的互连性,以及与丘脑、下丘脑、基底前脑和额叶皮层的连通性,这与动物研究和觉醒区域的预期一致。

所有觉醒和运动核的整体图测量和横向指数

运动脑干核显示出与小脑、基底神经节和运动皮层的预期连接,以及高度的互连性。3T和7T连接结果的对比表明,该研究脑干连接体方法与常规fMRI相比具有良好的可译性,特别是对于皮质和皮质下(非脑干)目标,脑干的可译性较低。18个觉醒和运动脑干核的功能连接体与大脑的其他部分可能会提供更好的了解觉醒、睡眠和伴随的人类健康和疾病的运动功能

总之,该研究提供了一个觉醒-运动脑干核的连接体,以及人觉醒和运动静息态功能网络的图。这项工作是基于最近开发的基于人的高分辨率7TMRI的概率脑干图谱。此外,通过比较3T数据连接体结果和7T结果,证明了该研究连接体在传统成像中的可译性。这些结果可能为未来研究脑干连接在健康和疾病中的基础。

原文出处

Functional connectome of arousal and motor brainstem nuclei in living humans by 7 Tesla resting-state fMRI

https://doi.org/10.1016/j.neuroimage.2021.118865

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    2022-05-25 guoyibin
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有报道称20%的人有抑郁症状,这些症状与大规模大脑网络功能完整性的改变有关。时时刻刻的大脑功能和抑郁症状之间的联系,以及这些关系对临床和社区人群的影响,仍然没有得到充分的研究。重度抑郁症(MDD)是世