Semin Arthritis Rheu:全手近红外光谱成像:一种评估硬皮病组织灌注和外周微循环的新工具

2018-08-22 xiangting MedSci原创

NIRS-2D成像是一种简单、自动化的工具,可以无创检测SSc中的局部微循环障碍。

系统性硬化症(SSc)会造成功能性和结构性微循环障碍,也会影响远端肢体。血液HbO2饱和度(stO2)的光学近红外光谱(NIRS)可以评估组织中的O2运输/消耗平衡。NIRS敏感相机能够非侵入性地检测浅表组织中的stO2值,并实时自动生成2D成像图。这项研究目的是与对照相比,在SSc患者中测试NIRS手部成像是否可以评估外周微循环障碍及其空间异质性。

使用手掌NIRS-2D成像研究了40例SSc患者(年龄55.1±15.6岁)和21例健康对照(年龄54.3±14.5岁,p=0.89)。前臂配带血压袖带从而诱导产生3分钟的缺血。在基线获取图像,然后缺血3分钟和再灌注5分钟期间每10秒获取一次。五个重点区域定位在第二到第五指的指尖、鱼际隆起1个。

对照组和SSc患者的基线stO2(84.3±7.5 vs 75.4±10.9%,p<0.001)、最小stO2(65.2±8.0 vs 53.4±10.1%,p<0.001)和充血期间达到最大stO2的时间(63±38 vs 85±49秒,p<0.05)存在显著差异。在临床特征中,抗Scl70抗体阳性、肢端溃疡病史和吸烟会影响NIRS参数,西地那非和他汀类药物也会造成影响。相反,不同的甲襞-视频毛细管显微镜检查类型之间的NIRS-2D值没有显著差异。

NIRS-2D成像是一种简单、自动化的工具,可以无创检测SSc中的局部微循环障碍,这种检查为甲襞-视频毛细管显微镜检查的形态学图像增加了重要的功能学信息。

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    2018-08-24 zhaojie88
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    2018-08-24 rgjl
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    2018-08-22 183****7028

    学习

    0

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激光多普勒成像流量数据不支持使用Btx-A来治疗所有硬皮病患者的RP。

Plos One:抗纤维化治疗的新型药物靶点!

硬皮病具有一定的临床特征,包括皮肤和其他组织纤维化,但目前抗纤维化的治疗尚不充分。卤夫酮(Halofuginone,HF)是目前临床前和临床研究中众所周知的抗纤维化药物,它可以通过抑制TGF-/Smad3信号通路发挥作用。最近,有研究表明脯氨酰-tRNA合成酶(PRS)是HF的靶蛋白,其可以与PRS的催化结构域的脯氨酸结合位点结合。近期,一项发表在杂志Plos One的研究描述了一类新的PRS抑制

Sci Transl Med:利用药物ABT-263让肌成纤维细胞靶向凋亡可逆转纤维化

在一项新的研究中,一个国际研究小组发现药物navitoclax能够导致小鼠中的肌成纤维细胞凋亡,从而降低硬皮病(scleroderma)中的纤维化扩散。相关研究结果发表在2017年12月13日的Science Translational Medicine期刊上,论文标题为“Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-2

NEJM:清髓性自体造血干细胞移植治疗重度硬皮病

研究认为,清髓性自体造血干细胞移植可使硬皮病患者获得长期受益,表现为无事件生存以及总生存期延长

Ann Rheum Dis:自身抗体和硬皮病表型可以定义癌症高危和低危亚组

自身抗体特异性和疾病亚型是具有生物学意义的过滤器,可以指导硬皮病患者的癌症风险分层。