Inflammopharmacology:褪黑激素可作为非手术治疗牙周炎的辅助疗法

2022-06-13 sunshine MedSci原创

近日,发表于Inflammopharmacology的一项系统只顾和荟萃分析评价了补充褪黑激素对非手术牙周治疗后临床结果的影响。

近日,发表于Inflammopharmacology的一项系统只顾和荟萃分析评价了补充褪黑激素对非手术牙周治疗后临床结果的影响。

研究人员在PubMed、Embase和Web of Science数据库中系统地检索了从开始到2021年5月的褪黑激素辅助治疗牙周炎的随机对照试验(RCTs)。该系统回顾是根据系统回顾和元分析的首选报告项目指南进行的,并在国际系统回顾前瞻性登记册(PROSPERO)上注册(CRD42021250630)。根据《Cochrane干预措施系统回顾手册》对纳入研究进行偏倚风险评估。通过随机效应模型计算集合效应估计,结果以加权平均差异(WMD)表示。

结果,荟萃分析中包括了7项RCTs,包括412名参与者。汇总结果显示,与单纯非手术治疗相比,在非手术牙周治疗中辅助使用褪黑激素可显著改善探诊深度(PD)[WMD=-1.18,95%CI(-1.75,-0.62)I2=85. 7%],临床附着水平(CAL)[WMD = - 1.16, 95% CI (- 1.60, - 0.72) I2 = 76.7%]和牙龈指数(WMD = - 0.29, 95%CI [- 0.48, - 0.11], I2 = 63.6%)。此外,亚组分析结果显示,与低剂量褪黑激素(<3毫克)相比,补充高剂量的褪黑激素(3-10毫克)可明显改善PD[WMD = - 1.32, 95%CI (- 2.31, - 0.15) I2 = 93%]和CAL[WMD = - 1.30, 95%CI (- 1.80, - 0.81) I2 = 73.7%] 。

综上所述,该研究结果表明,在非手术治疗后,辅助性补充褪黑激素可以显著改善患者的牙周状况,这表明当单独的非手术牙周治疗不能达到预期的改善效果时,补充褪黑激素可能是一种新的牙周炎辅助治疗方法。

原始出处:

Ru-Yue Liu, et al., Clinical efficacy of melatonin as adjunctive therapy to non-surgical treatment of periodontitis: a systematic review and meta-analysis. Inflammopharmacology. 2022 Jun;30(3):695-704. doi: 10.1007/s10787-022-00959-3.  

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  5. 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time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451388, encodeId=d0001451388b0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 15 03:57:48 CST 2022, time=2022-06-15, status=1, ipAttribution=)]
    2022-10-18 yb6560
  6. 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time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451388, encodeId=d0001451388b0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 15 03:57:48 CST 2022, time=2022-06-15, status=1, ipAttribution=)]
    2022-11-13 lxg951
  7. 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