Br J Cancer:体育活动、握力和久坐行为与恶性黑色素瘤发病风险之间的相关性研究

2021-06-01 xiaozeng MedSci原创

体育活动是预防各种癌症风险的一种保护因素,最有力的证据表现在结肠癌和乳腺癌的预防上。

体育活动是预防各种癌症风险的一种保护因素,最有力的证据表现在结肠癌乳腺癌的预防上。握力作为肌肉力量的替代指标,其是体能的组成部分,且也已被证实与结直肠癌、乳腺癌和肺癌的发病呈负相关。

先前的前瞻性队列研究表明,体育锻炼与恶性黑色素瘤发病风险之间存在着正相关性,而这种关联性可能会与紫外线辐射(UV)混淆。


紫外线辐射是与户外体育活动和恶性黑色素瘤密切相关的一个变量。在该研究中,研究人员旨在探究与恶性黑色素瘤发病风险相关的体力活动、握力和久坐行为,并通过分析前瞻性队列研究数据以解释相关混杂因素。

研究人员通过分析英国生物样本库中年龄在38-73岁之间的350,512名参与者的数据,使用国际体育活动问卷修改版简表来评估参与者的体育活动状况,并使用手部测力计测量握力,以及通过三个特定问题记录参与者的久坐行为习惯。研究人员采用Cox比例风险回归模型评估多变量风险比(HR)和相应的95%置信区间(CI)。


结果显示,在7年的随访中,共记录了1239例恶性黑色素瘤。研究人员发现,恶性黑色素瘤与体育活动和久坐行为无关(HR分别为1.01和1.04),且在基本模型中与握力呈正相关性(HR=1.23),但在进行调整后该相关性减弱(HR=1.10)。

相关研究流程图

总而言之,该研究结果揭示,体育活动、握力和久坐行为与恶性黑色素瘤的发病风险无关。


原始出处:

Weber, A., Leitzmann, M.F., Sedlmeier, A.M. et al. Association between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank. Br J Cancer (31 May 2021).

 

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    2021-09-15 syscxl
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    2022-03-31 sunylz
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    2021-06-01 医鸣惊人

    认真学习了

    0

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