A&R:通过血清蛋白质组分析鉴定全身性幼年特发性关节炎和相关肺病的不同炎症程序和生物标志物

2022-07-31 MedSci原创 MedSci原创

选择的生物标志物,例如 ICAM-5,可以帮助SJIA-LD的早期检测和管理。

目的最近对全身性幼年特发性关节炎(JIA)的观察表明,高死亡率间质性肺病的发病率正在增加,通常以肺泡蛋白沉积症(PAP)的变异为特征。全身性JIA中巨噬细胞活化综合征(MAS)PAP的共同发生表明存在共同的病理学,但患有与全身性JIA相关的肺部疾病(称为SJIA-LD)的患者也通常会出现药物反应的特征,例如非典型皮疹和嗜酸性粒细胞增多。本研究旨在调查免疫病理学并确定全身JIAMASSJIA-LD中的生物标志物。

方法使用SOMAscan测量了健康对照和全身性JIAMASSJIA-LD或其他相关疾病患者血清中约1300种分析物。通过酶联免疫吸附测定和肺免疫染色验证了选定的发现。因为样本的蛋白质组可能反映多种状态(全身JIAMASSJIA-LD),使用了回归模型来识别与每种状态相关的改变蛋白质的子集。在验证队列中测试了关键发现。

结果活跃的全身性JIAMAS的蛋白质组改变有很大的重叠,包括已知的全身性JIA 生物标志物,如血清淀粉样蛋白AS100A9,以及热休克蛋白和糖酵解酶水平的新升高。所有全身性JIA组,尤其是MASSJIA-LDIL-18水平均升高。还发现了一个 MAS无关的SJIA-LD特征,其显著的细胞间粘附分子5 (ICAM-5)、基质金属蛋白酶7 (MMP-7)和过敏/嗜酸性趋化因子水平升高,这些以前与肺损伤有关。免疫组织化学将 ICAM-5MMP-7定位在SJIA-LD患者的肺部。ICAM-5区分SJIA-LD和系统性 JIA/MAS的能力得到了独立验证。

结论血清蛋白支持系统的JIAMAS的连续状态,帮助区分系统性JIA、系统性JIA/MAS SJIA-LD,并提出病因学假设。选择的生物标志物,例如 ICAM-5,可以帮助SJIA-LD的早期检测和管理。

 

出处:

Chen G, Deutsch GH, Schulert GS, et al. Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis. Arthritis Rheumatol. 2022 Jul;74(7):1271-1283. doi: 10.1002/art.42099. Epub 2022 May 31. PMID: 35189047; PMCID: PMC9246966.

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    2022-09-12 amy0559
  6. [GetPortalCommentsPageByObjectIdResponse(id=1754885, encodeId=f3d01e5488528, content=<a href='/topic/show?id=0a1688e33b3' target=_blank style='color:#2F92EE;'>#蛋白质组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88733, encryptionId=0a1688e33b3, topicName=蛋白质组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cf6736789983, createdName=jjjiang0211, createdTime=Wed Nov 23 09:39:20 CST 2022, time=2022-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841917, encodeId=02af184191e7a, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Sep 22 16:39:20 CST 2022, time=2022-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894865, encodeId=e1dd18948655f, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Dec 19 18:39:20 CST 2022, time=2022-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765981, encodeId=f1201e65981ef, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Dec 06 01:39:20 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671998, encodeId=45a516e1998fa, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Mon Sep 12 04:39:20 CST 2022, time=2022-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266503, encodeId=4d591266503fd, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Jul 31 11:39:20 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297177, encodeId=dd94129e1770f, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Jul 31 11:39:20 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561174, encodeId=2bf915611e4f1, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Jul 31 11:39:20 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567183, encodeId=9707156e18359, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Jul 31 11:39:20 CST 2022, time=2022-07-31, status=1, ipAttribution=)]
    2022-07-31 lmm397
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