Heart:肝细胞生长因子作为冠心病的生物标志物具有种族异质性!

2017-06-02 xing.T MedSci原创

在这个大型不同人群为基础的队列中,研究人员报道了HGF与亚临床CHD和CHD发生相关。研究人员证实了这些相关性中种族/族裔存在异质性,结果在非裔美国人和非西班牙裔白人中最为引人注目。该研究提供的证据表明HGF是动脉粥样硬化疾病的生物标志物,并且独立于传统的危险因素。

由于介入治疗和支持疗法的最新进展,对急性和严重主动脉瓣狭窄失代偿患者的最佳治疗尚不清楚。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在评估紧急经导管主动脉瓣植入术(eTAVI)与紧急球囊主动脉瓣成形术(eBAV)后TAVI的早期疗效结局。

肝细胞生长因子(HGF)是一个有前景的冠状动脉心脏疾病(CHD)生物标志物,其释放到循环中对内皮损伤作出应答,近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在明确HGF是否与不同种族/民族的人群亚临床临床CHD相关。

研究人员测量了动脉粥样硬化多民族研究(MESA研究)6738名参与者的HGF水平。依次观察西班牙裔、非洲裔、非西班牙裔白人、华裔美国人中最高的平均HGF值(pg/ml)。

在所有种族/民族中,HGF水平与年龄较大、收缩压(SBP)较高、体重指数较大、低高密度脂蛋白高水平、糖尿病和吸烟相关。在充分调整的模型中,HGF每增加一个SD,冠状动脉钙化(CAC)在非西班牙裔白中平均增加55钙化单位(P<0.001),在非裔美国人中增加51钙化单位(P=0.007),但在其他种族/族裔群体中不增加(交互作用P=0.02)。有529次冠心病事件发生,HGF水平每增加一个SD,在在非洲裔人群中CHD风险增加41%(P<0.001),在非西班牙裔白人(P=0.026)和华裔(P=0.36)人群中增加17%,西班牙裔美国人增加6%(P=0.56)。

在这个大型不同人群为基础的队列中,研究人员报道了HGF与亚临床CHD和CHD发生相关。研究人员证实了这些相关性中种族/族裔存在异质性,结果在非裔美国人和非西班牙裔白人中最为引人注目。该研究提供的证据表明HGF是动脉粥样硬化疾病的生物标志物,并且独立于传统的危险因素。

原始出处:

Suzette J Bielinski,et al. Hepatocyte growth factor demonstrates racial heterogeneity as a biomarker for coronary heart disease. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2016-310450

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    2018-03-28 xjy02
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205652, encodeId=c34f2056525d, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Jun 02 13:44:41 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
    2017-06-04 zhaojie88
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205652, encodeId=c34f2056525d, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Jun 02 13:44:41 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205652, encodeId=c34f2056525d, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Jun 02 13:44:41 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205652, encodeId=c34f2056525d, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Jun 02 13:44:41 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
    2017-06-04 slcumt
  8. 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205652, encodeId=c34f2056525d, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Jun 02 13:44:41 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
    2017-06-02 天涯183

    非常好的文章,学习了,很受益

    0

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