JAMA Dermatol:银屑病和银屑病关节炎患者的患病率、发病率和癌症发病风险

2022-01-14 MedSci原创 MedSci原创

当前银屑病与癌症风险之间的关系仍有待商榷。近日,发表于JAMA Dermatol的一项研究评估了银屑病或银屑病关节炎患者的癌症关联和风险,包括特定癌症亚型的风险。

当前银屑病与癌症风险之间的关系仍有待商榷。近日,发表于JAMA Dermatol的一项研究评估了银屑病或银屑病关节炎患者的癌症关联和风险,包括特定癌症亚型的风险。

研究人员筛选了两个数据库(PubMed和Embase),检索截止至2019年1月1日上述数据库收录的相关文献,纳入包括有银屑病或银屑病关节炎患者群体的观察性队列研究。研究必须是原创的,并报告该人群中癌症的发病率或流行率。

检索结果显示,共有365项研究被纳入全文评估。由于纳入的研究存在异质性,因此采用了随机效应模型。主要结果是癌症(总体和特定亚型),衡量标准是银屑病或银屑病关节炎患者的癌症流行率、发病率和风险估计。在评估的365项研究中,112项被纳入分析(N = 2 053 932名患者)。

分析结果显示,银屑病患者的癌症总患病率为4.78%(95% CI,4.02%-5.59%),发病率为11.75/1000人-年(95% CI,8.66-15.31),风险比(RR)为1.21(95% CI,1.11-1.33)。有几种癌症的风险增加,包括角质细胞癌(RR,2.28;95% CI,1.73-3.01),淋巴瘤(RR,1.56;95% CI,1.37-1.78),肺癌(RR,1.26;95% CI,1.13-1.40)和膀胱癌(RR,1.12;95% CI,1.04-1.19)。未发现使用生物制剂治疗的银屑病患者的癌症风险增加(RR,0.97;95% CI,0.85-1.10)。银屑病关节炎与总体癌症风险的增加无关(RR,1.02;95% CI,0.97-1.08)。

综上所述,该研究结果表明,银屑病患者的癌症风险似乎略有增加,尤其是角质细胞癌和淋巴瘤。有关生物制剂治疗的数据没有显示癌症风险增加。有关银屑病关节炎患者癌症的数据仍然很少,需要在该领域进行进一步研究。

原始出处:

Sofie Vaengebjerg, et al., Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-analysis. JAMA Dermatol. 2020 Apr 1;156(4):421-429. doi: 10.1001/jamadermatol.2020.0024.

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    2022-01-27 maotouying

    谢谢分享,很不错👍

    0

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    2022-01-16 lmm397

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