Ann Oncol:绝经后女性口服双磷酸盐或能预防肺癌

2018-07-12 吴星 环球医学

2018年6月,发表在《Ann Oncol》的一项由美国学者进行的研究,考察了绝经后女性口服双磷酸盐与肺癌发病率之间的相关性。

2018年6月,发表在《Ann Oncol》的一项由美国学者进行的研究,考察了绝经后女性口服双磷酸盐与肺癌发病率之间的相关性。

背景:双磷酸盐是老年人群治疗骨质疏松的常用药物。包括妇女健康倡议(WHI)在内的一些研究已经发现,双磷酸盐的使用与乳腺癌和子宫内膜癌风险之间具有负相关性,但是其与其他常见恶性肿瘤之间的相关性知之甚少。本研究旨在评估WHI中,双磷酸盐的使用与肺癌发病率之间的相关性。

患者和方法:在1993~1998年纳入WHI的151432名绝经后女性中考察口服双磷酸盐与肺癌风险之间的相关性。在基线和随访期,参与者完成了包括双磷酸盐在内的定期用药清单。

结果:平均随访13.3年后,2511名女性诊断为肺癌。无证据显示双磷酸盐使用者和未使用者之间肺癌发病率存在差异(调整风险比[HR]=0.91;95% 置信区间[CI],0.80~1.04;P=0.16)。然而,在非吸烟者中观察到负相关性(HR=0.57;95% CI,0.39~0.84;P<0.01)。

结论:在这项绝经后女性组成的大型前瞻性队列中,口服双磷酸盐与非吸烟者肺癌风险显著较低相关,表明双磷酸盐对肺癌具有预防作用。需要额外的研究来证实此结果。

原始出处:

Tao MH, Chen S, Freudenheim JL, et.al. Oral bisphosphonate use and lung cancer incidence among postmenopausal women. Ann Oncol. 2018 Jun 1;29(6):1476-1485. doi: 10.1093/annonc/mdy097.

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    2018-11-03 minlingfeng
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    2018-07-14 zxxiang

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