JAHA:肥厚性心肌病患者抑郁症与临床结局之间的关系

2021-04-09 MedSci原创 MedSci原创

抑郁症在HCM患者中很常见。抑郁症的诊断与HCM患者SCD事件和心力衰竭事件的风险增加显著且独立相关。

肥厚型心肌病(HCM)被认为是年轻人猝死的最常见原因,并且与情绪障碍的风险增加有关。抑郁症已成为冠状动脉疾病发生和进展的关键危险因素。然而,抑郁症与HCM患者结局之间的关联尚未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员试图评估抑郁症对HCM患者临床结局的影响。

在2014年1月至2017年12月之间,研究人员共招募了820例HCM患者,平均随访4.2年。终点事件定义为心源性猝死(SCD)和与HCM相关的心力衰竭事件。研究人员通过第五版精神障碍诊断和统计手册诊断了受试者抑郁症情况。

在随访期间,75名受试者(每1000人每年21.8人)发生SCD事件,149名受试者(每1000人每年43.3人)发生HCM相关的心力衰竭事件。Kaplan-Meier累积发生率曲线显示抑郁症与SCD事件(log-rank P=0.001)和HCM相关的心力衰竭事件(log-rank P=0.005)显著相关。多元Cox回归分析表明,抑郁症是SCD事件和HCM相关性心力衰竭事件的独立预测因子(每1000人每年41.9人 vs. 21.7;调整后的风险比[HR]为1.9;95%CI为1.6-2.3; P<0.001;69.9 vs. 38.6/1000人每年;HR为1.8;95%CI为1.6-2.1;P<0.001)。

由此可见,抑郁症在HCM患者中很常见。抑郁症的诊断与HCM患者SCD事件和心力衰竭事件的风险增加显著且独立相关。

原始出处:

Hui‐Lin Hu.et al.Association Between Depression and Clinical Outcomes in Patients With Hypertrophic Cardiomyopathy.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019071

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    2021-04-10 zyz168666

    抑郁和焦虑越来越常见

    0

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    2021-04-10 ms2000002099164425

    666

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    2021-04-09 ms5000000892437705

    感谢好文!

    0

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