JAMA:孕期接种流感疫苗不会增加幼儿不良健康结局风险

2021-06-09 MedSci原创 MedSci原创

孕期接种流感疫苗是安全的

全球范围内,季节性流感每年会影响大约5%-10%的成年人以及20%-30%的儿童。孕妇不是流感的易感人群,但感染后患严重流感疾病和相关并发症的风险增加。统计发现,2009年A型流感(H1N1)病毒([h1n1]pdm09)大流行期间,胎儿死亡和早产风险显著增加,但由于担心疫苗接种后对胎儿的不良影响,许多孕妇不愿意接种疫苗。近日研究人员考察了妊娠期接种季节性流感疫苗与幼儿健康结局的关系

本次研究为回顾性队列研究,2010年10月1日至2014年3月31日期间,加拿大新斯科舍省的所有活产婴儿参与研究,随访至2016年3月31日。收集孕妇怀孕期间接种季节性流感疫苗数据。研究的主要终点幼儿免疫相关性疾病(如哮喘、感染)、非免疫相关性疾病(如肿瘤、感觉障碍)和医疗事件(如急诊或住院)风险。

总计28255名儿童参与研究,其中女童占49%,妊娠37周以上新生儿占92%,10227名(36.2%)新生儿母亲在怀孕期间接种了季节性流感疫苗。在平均3.6年的随访中,母亲接种流感疫苗与幼儿哮喘(发病率为3.0 vs 2.5/1000人年)、肿瘤(0.32 vs 0.26/1000人年)、感觉功能障碍(0.80 vs 0.97/1000人年)、儿童早期感染(184.6 vs 179.1/1000人-年)以及急诊和住院风险无关(511.7 vs 477.8/1000人年)。

研究认为,孕期母亲接种流感疫苗不会增加幼儿不良健康结局风险,孕期接种流感疫苗是安全的。

原始出处:

Azar Mehrabadi et al. Association of Maternal Influenza Vaccination During Pregnancy With Early Childhood Health Outcomes. JAMA. June 06,2021.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2054222, encodeId=a318205422223, content=<a href='/topic/show?id=82fa2e92623' target=_blank style='color:#2F92EE;'>#健康结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27926, encryptionId=82fa2e92623, topicName=健康结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Sun Dec 19 00:04:01 CST 2021, time=2021-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977671, encodeId=64d29e7671ba, content=安全性提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83er2icISIlFBOOS0O4UuL65GeGuiaYU2bHQUE0QIfxanf4k9COMcrBxPXILGN1zln7NcvDDicEqR5UMqg/132, createdBy=68162475471, createdName=ms6169241532840991, createdTime=Mon Jun 28 19:30:39 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972427, encodeId=1d399e242737, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4a35491076, createdName=ms4000000101002478, createdTime=Thu Jun 10 10:20:30 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036663, encodeId=88841036663d4, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jun 10 00:04:01 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972305, encodeId=87859e2305b9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201001/da991e6f2337466dbebad1d121d0c02b/5a96efec3603455082013ec8385f01ed.jpg, createdBy=a01b5135178, createdName=医孩, createdTime=Wed Jun 09 22:34:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-28 ms6169241532840991

    安全性提高了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2054222, encodeId=a318205422223, content=<a href='/topic/show?id=82fa2e92623' target=_blank style='color:#2F92EE;'>#健康结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27926, encryptionId=82fa2e92623, topicName=健康结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Sun Dec 19 00:04:01 CST 2021, time=2021-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977671, encodeId=64d29e7671ba, content=安全性提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83er2icISIlFBOOS0O4UuL65GeGuiaYU2bHQUE0QIfxanf4k9COMcrBxPXILGN1zln7NcvDDicEqR5UMqg/132, createdBy=68162475471, createdName=ms6169241532840991, createdTime=Mon Jun 28 19:30:39 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972427, encodeId=1d399e242737, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4a35491076, createdName=ms4000000101002478, createdTime=Thu Jun 10 10:20:30 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036663, encodeId=88841036663d4, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jun 10 00:04:01 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972305, encodeId=87859e2305b9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201001/da991e6f2337466dbebad1d121d0c02b/5a96efec3603455082013ec8385f01ed.jpg, createdBy=a01b5135178, createdName=医孩, createdTime=Wed Jun 09 22:34:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-10 ms4000000101002478

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2054222, encodeId=a318205422223, content=<a href='/topic/show?id=82fa2e92623' target=_blank style='color:#2F92EE;'>#健康结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27926, encryptionId=82fa2e92623, topicName=健康结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Sun Dec 19 00:04:01 CST 2021, time=2021-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977671, encodeId=64d29e7671ba, content=安全性提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83er2icISIlFBOOS0O4UuL65GeGuiaYU2bHQUE0QIfxanf4k9COMcrBxPXILGN1zln7NcvDDicEqR5UMqg/132, createdBy=68162475471, createdName=ms6169241532840991, createdTime=Mon Jun 28 19:30:39 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972427, encodeId=1d399e242737, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4a35491076, createdName=ms4000000101002478, createdTime=Thu Jun 10 10:20:30 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036663, encodeId=88841036663d4, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jun 10 00:04:01 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972305, encodeId=87859e2305b9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201001/da991e6f2337466dbebad1d121d0c02b/5a96efec3603455082013ec8385f01ed.jpg, createdBy=a01b5135178, createdName=医孩, createdTime=Wed Jun 09 22:34:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-10 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2054222, encodeId=a318205422223, content=<a href='/topic/show?id=82fa2e92623' target=_blank style='color:#2F92EE;'>#健康结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27926, encryptionId=82fa2e92623, topicName=健康结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Sun Dec 19 00:04:01 CST 2021, time=2021-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977671, encodeId=64d29e7671ba, content=安全性提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83er2icISIlFBOOS0O4UuL65GeGuiaYU2bHQUE0QIfxanf4k9COMcrBxPXILGN1zln7NcvDDicEqR5UMqg/132, createdBy=68162475471, createdName=ms6169241532840991, createdTime=Mon Jun 28 19:30:39 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972427, encodeId=1d399e242737, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4a35491076, createdName=ms4000000101002478, createdTime=Thu Jun 10 10:20:30 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036663, encodeId=88841036663d4, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jun 10 00:04:01 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972305, encodeId=87859e2305b9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201001/da991e6f2337466dbebad1d121d0c02b/5a96efec3603455082013ec8385f01ed.jpg, createdBy=a01b5135178, createdName=医孩, createdTime=Wed Jun 09 22:34:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-09 医孩

    学习

    0

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