Cardiovasc Diabetol:甘油三酯葡萄糖指数与冠心病患者颈动脉斑块的相关性

2022-03-13 Nebula MedSci原创

甘油三酯葡萄糖指数与冠心病患者是否存在颈动脉斑块具有显著相关性

甘油三酯葡萄糖 (TyG) 指数可作为胰岛素抵抗的替代指标。但是,目前关于 TyG 指数与冠心病 (CHD) 患者颈动脉斑块 (CAP) 之间的相关性的证据有限。

在该研究中,10535 位冠心病患者根据 TyG 指数被分成了四组(Q1: TyG 指数 <8.52; Q2: 8.52≤TyG 指数 <8.93; Q3: 8.93≤TyG 指数 ≤9.40; Q4: TyG 指数>9.40)。通过颈动脉超声检查确定是否存在颈动脉粥样硬化斑块。采用 Logistic回归分析冠心病患者的 TyG 指数与 CAP 的相关性。同时,研究人员还评估了根据性别、年龄和葡萄糖代谢状态调整的 TyG 指数和 CAP 之间的关系。

TyG指数与CAP在总患者中的相关性

基线分析显示,根据 TyG 指数四分位数划分的四组冠心病患者的相关参数存在显著差异。在多重调整模型中,与 TyG 指数的 Q1 组相比,TyG 指数的 Q4 组的 CHD 患者存在 CAP 的优势比(OR)为1.37。TyG 指数与 CAP 的相关性在女性(OR 1.35)比在男性(OR 1.20)中更强。TyG 指数与 CAP 在中年人(≤60岁)中的相关性强于老年人(>60岁)。

TyG指数与CAP在不同糖代谢状态患者中的相关性

在不同的糖代谢状态下,CHD 患者合并糖尿病时,TyG 指数与 CAP 风险的相关性最强(OR 1.36)。

总结示意图

综上,甘油三酯葡萄糖指数与冠心病患者是否存在颈动脉斑块具有显著相关性。该相关性在女性(相比男性)和中年人(相比老年人)中更突出。患者合并糖尿病的情况下,甘油三酯葡萄糖指数与颈动脉斑块的相关性最高。

原始出处:

Li, Z., He, Y., Wang, S. et al. Association between triglyceride glucose index and carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China. Cardiovasc Diabetol 21, 38 (2022). https://doi.org/10.1186/s12933-022-01470-3

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    2023-02-07 quxin068
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  5. 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  6. 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channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Tue Mar 15 13:48:44 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447805, encodeId=5802144e80597, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Tue Mar 15 13:48:44 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202399, encodeId=5efc120239983, content=新指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Mon Mar 14 10:14:34 CST 2022, time=2022-03-14, status=1, ipAttribution=)]
    2022-05-03 maotouying

    很不错的研究,学习了,感谢了

    0

  7. 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    2022-03-14 医者仁者

    新指标

    0

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