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JCO：HIF-2α拮抗剂PT2385治疗晚期透明细胞肾癌

2017-12-20 MedSci MedSci原创

透明细胞肾癌HIF-2α拮抗剂PT2385
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大部分透明细胞肾癌患者中均存在HIF-2α不稳定。PT2385是第一类HIF-2α拮抗剂。JCO近期发表了一篇文章，报道PT2385治疗透明细胞肾癌的Ⅰ期临床试验结果。

大部分透明细胞肾癌患者中均存在HIF-2α不稳定。PT2385是第一类HIF-2α拮抗剂。JCO近期发表了一篇文章，报道PT2385治疗透明细胞肾癌的Ⅰ期临床试验结果。

研究纳入的患者为接受一个及以上方案治疗病情进展的局部晚期或转移性透明细胞肾癌。每天两次口服PT2385，根据3+3剂量递增设计，剂量为100-1800mg，而后进行推荐Ⅱ期剂量扩展。剂量递增队列和扩展队列分别纳入患者26人和25人。患者均接受过治疗，接受过的中位治疗方案数量为4种。任何剂量水平均未发现剂量限制毒性。在安全性、药代动力学、药效学特征基础上，推荐Ⅱ期剂量为800mg每天两次。PT2385耐受性良好，常见的不良反应为贫血、外周水肿和虚弱。没有患者因不良反应中断治疗。完全缓解率为2%，部分缓解率为12%，病情稳定率为52%。在数据收集截止时，8例患者仍在研究之中，13例患者进行研究时间超过1年。

文章最后认为，PT2385安全性良好且在接受过治疗的透明细胞肾癌患者中具有抗肿瘤活性，表明HIF-2α拮抗剂在透明细胞肾癌患者中具有直接的治疗作用。

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    2018-09-16 liubm555

    #PT2385#

    0

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    2018-11-23 lidong40

    #JCO#

    0

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    2017-12-25 wxl882001

    了解一下

    0

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    2017-12-22 ms5236388012055669

    #拮抗剂#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1958328, encodeId=33331958328d5, content=<a href='/topic/show?id=bdee14826b5' target=_blank style='color:#2F92EE;'>#PT2385#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14826, encryptionId=bdee14826b5, topicName=PT2385)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=976a57, createdName=liubm555, createdTime=Sun Sep 16 03:17:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891470, encodeId=8dd218914e052, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Fri Nov 23 04:17:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272456, encodeId=62952e2456ea, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Dec 25 18:31:51 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511687, encodeId=346f151168e1d, content=<a href='/topic/show?id=90d75628960' target=_blank style='color:#2F92EE;'>#拮抗剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56289, encryptionId=90d75628960, topicName=拮抗剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474c10379153, createdName=ms5236388012055669, createdTime=Fri Dec 22 06:17:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556030, encodeId=f25415560305b, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=293014689254, createdName=wrj0126, createdTime=Fri Dec 22 06:17:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270994, encodeId=70652e09942a, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 20 20:54:45 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270974, encodeId=6d2b2e097483, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Wed Dec 20 19:21:19 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270958, encodeId=3b952e0958e1, content=好自恋好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Dec 20 17:54:16 CST 2017, time=2017-12-20, status=1, ipAttribution=)]
    2017-12-22 wrj0126

    #HIF#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1958328, encodeId=33331958328d5, content=<a href='/topic/show?id=bdee14826b5' target=_blank style='color:#2F92EE;'>#PT2385#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14826, encryptionId=bdee14826b5, topicName=PT2385)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=976a57, createdName=liubm555, createdTime=Sun Sep 16 03:17:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891470, encodeId=8dd218914e052, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Fri Nov 23 04:17:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272456, encodeId=62952e2456ea, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Dec 25 18:31:51 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511687, encodeId=346f151168e1d, content=<a href='/topic/show?id=90d75628960' target=_blank style='color:#2F92EE;'>#拮抗剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56289, encryptionId=90d75628960, topicName=拮抗剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474c10379153, createdName=ms5236388012055669, createdTime=Fri Dec 22 06:17:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556030, encodeId=f25415560305b, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=293014689254, createdName=wrj0126, createdTime=Fri Dec 22 06:17:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270994, encodeId=70652e09942a, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 20 20:54:45 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270974, encodeId=6d2b2e097483, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Wed Dec 20 19:21:19 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270958, encodeId=3b952e0958e1, content=好自恋好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Dec 20 17:54:16 CST 2017, time=2017-12-20, status=1, ipAttribution=)]
    2017-12-20 三生有幸9135

    学习一下谢谢分享

    0

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    2017-12-20 戒馋，懒，贪

    谢谢分享学习了

    0

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    2017-12-20 thlabcde

    好自恋好资料学习了!

    0