Plos One:1型糖尿病患者血清中肿瘤坏死因子α水平的变化

2017-04-22 MedSci MedSci原创

近期,一项发表在杂志Plos One上的研究旨在评估1型糖尿病(T1DM)患者的血清中肿瘤坏死因子-α(TNF-α)的变化情况。此项研究从PubMed、Cochrane图书馆、CNKI、万方和中国Cqvip数据库(1999年1月1日至2016年9月30日发表)中筛选了相关文献。对血清TNF-α水平进行了汇总分析,并与年龄、病程和种族关系进行亚组分析。此项荟萃分析共纳入23篇文章(1631例T1DM

近期,一项发表在杂志Plos One上的研究旨在评估1型糖尿病(T1DM)患者的血清中肿瘤坏死因子-α(TNF-α)的变化情况。

此项研究从PubMed、Cochrane图书馆、CNKI、万方和中国Cqvip数据库(1999年1月1日至2016年9月30日发表)中筛选了相关文献。对血清TNF-α水平进行了汇总分析,并与年龄、病程和种族关系进行亚组分析。

此项荟萃分析共纳入23篇文章(1631例T1DM病例,1429例健康对照)。与对照组相比,T1DM患者血清中TNF-α水平显着升高(P <0.001)。在不同年龄、疾病持续时间和种族(亚洲除外)的亚组分析中,也发现类似的结果(均P <0.05)。回归分析显示,患者年龄(P = 0.680)、病程(P = 0.957)和种族(P = 0.526)对高异质性均不是显着性影响因素。此外,敏感性分析显示,此项研究结果稳定,荟萃分析中没有发表偏倚。

此项研究表明:T1DM患者的血清TNF-α水平在所有年龄、疾病持续时间和种族组间均有显着的升高。

原始出处:
Qiao YC, Chen YL, et al. The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis. PLoS One. 2017 Apr 20;12(4):e0176157. doi: 10.1371/journal.pone.0176157. eCollection 2017.

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    2017-04-30 绛珠草小姐

    学习了,谢谢分享

    0

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    2017-04-24 millore
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    2017-04-23 虈亣靌

    学习了很好的内容

    0

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    2017-04-23 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

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    2017-04-22 天涯183

    非常好的研究学习了,很受益。

    0

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