Clinica Chimica Acta:低HDL胆固醇血症中年男性饮酒与心血管危险因素的关系

2019-09-16 Gladiator MedSci原创

尽管轻度至中度饮酒可降低缺血性心脏病的风险,但酒精的这种影响主要是由酒精引起的高密度脂蛋白胆固醇升高所致。

尽管轻度至中度饮酒可降低缺血性心脏病的风险,但酒精的这种影响主要是由酒精引起的高密度脂蛋白胆固醇升高所致。 HDL胆固醇血症是心血管疾病的有效危险因素。本研究的目的是阐明酒精与低HDL胆固醇血症男性的心血管危险因素之间的关系。

本研究纳入的受试者为低HDL胆固醇血症(<40mg / dl)的中年男性,研究人员将其按每日饮酒量分为四组(非;轻,<22g乙醇/;中度,≥22g乙醇)和<44克乙醇/;重度饮酒者,≥44克乙醇/天)。在校正年龄和吸烟和定期运动的历史后,对各组之间的每个风险因素进行了比较。

研究发现,中度和重度饮酒者的收缩压和舒张压水平、log转化的脂质积累产物和log转化的心脏代谢指数明显高于不饮酒者。轻度、中度和重度饮酒者的log转化甘油三酯和甘油三酯与高密度脂蛋白胆固醇的比值显著高于不饮酒者,且随着酒精摄入量的增加,这一比值趋于升高。轻度、中度和重度饮酒者的LDL胆固醇和LDL胆固醇与hdl胆固醇的比值显著低于不饮酒者,且随着酒精摄入量的增加,LDL胆固醇和LDL胆固醇与hdl胆固醇的比值往往更低。在多元logistic回归分析中也发现了上述饮酒与心血管危险因素关系的趋势。

研究结果表明,在低HDL胆固醇血症的男性中,饮酒与血压和甘油三酯呈正相关,与LDL胆固醇呈负相关。

原始出处:

Ichiro WakabayashiRelationships between alcohol intake and cardiovascular risk factors in middle-aged men with hypo-HDL cholesterolemia

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    2020-03-25 windight
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    2019-09-18 ZGMFX24A
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