JAHA:HIV感染者社区获得性肺炎与心血管事件风险

2020-11-23 MedSci原创 MedSci原创

调整已知的CVD危险因素和CAP严重程度后,PLWH和未感染HIV的患者在CAP住院期间或之后发生CVD事件的风险相似。然而,在多变量校正模型中,HIV感染与CAP住院后30天死亡率增加相关。

感染HIV的患者因社区获得性肺炎(CAP)住院治疗会增加血管疾病(CVD)事件的风险。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在评估CAP住院后,HIV感染者(PLWH)是否比未感染HIV的个体具有更高的CVD或死亡风险。

研究人员分析了美国退伍军人老龄化队列研究2003年4月至2014年12月期间的数据 ,并使用Cox回归分析确定从入院之日起至出院后30天(30天死亡率)期间HIV感染状况是否与CVD事件和死亡率相关,并调整了已知的CVD危险因素。

研究人员纳入了4384例患者(67%[n=2951]PLWH)。与未感染HIV的CAP患者相比,因CAP住院的PLWH较年轻,CAP严重程度较低且CVD危险因素较少。在多变量校正分析中,与未感染HIV相比,PLWH个体的CVD风险相似(风险比[HR]为0.89;95%CI为0.70-1.12),但HIV感染与更高的死亡风险相关(HR为1.49;95%CI为1.16-1.90)。在按HIV状况分层的模型中,CAP严重程度与PLWH和未感染HIV的患者的CVD和30天死亡率显著相关。

由此可见,调整已知的CVD危险因素和CAP严重程度后,PLWH和未感染HIV的患者在CAP住院期间或之后发生CVD事件的风险相似。然而,在多变量校正模型中,HIV感染与CAP住院后30天死亡率增加相关。

原始出处:

Jerry S. Zifodya.et al.Community‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/10.1161/JAHA.120.017645

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    2020-12-09 ms5000000518166734

    学习了!受益匪浅

    0

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createdName=circumcision, createdTime=Wed Nov 25 13:17:06 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395886, encodeId=568d1395886ee, content=<a href='/topic/show?id=7a89e4036eb' target=_blank style='color:#2F92EE;'>#社区#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74036, encryptionId=7a89e4036eb, topicName=社区)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Wed Nov 25 13:17:06 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901964, encodeId=ded090196435, content=HIV感染与更高的死亡风险相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Nov 24 22:00:29 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-12-06 ms5000000518166734

    久违了,学习,学习!

    0

  5. 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createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Nov 24 22:00:29 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-30 ms5000000518166734

    受益匪浅,学习,学习。

    0

  6. 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    2020-11-25 zhaohui6731
  7. 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  8. 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  9. 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  10. 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    2020-11-24 Jessica

    HIV感染与更高的死亡风险相关

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