Dig Dis Sci: 胰腺囊肿患者发生胰腺癌的几率和癌症相关死亡率都较低

2021-04-05 MedSci原创 MedSci原创

胰腺囊肿的发生率通常在2-15%左右,主要包括良性囊性病变,例如假性囊肿和浆液性囊腺瘤,以及潜在的恶性囊肿,例如导管内乳头状粘液性肿瘤(IPMN)。

      胰腺囊肿的发生率通常在2-15%左右,主要包括良性囊性病变,例如假性囊肿和浆液性囊腺瘤,以及潜在的恶性囊肿,例如导管内乳头状粘液性肿瘤(IPMN)和粘液性囊性肿瘤(MCN)。但是,胰腺囊肿患者的胰腺癌发病率和死亡率尚不清楚。本项研究的目的是通过长期的随访来评估大样本人群中胰腺癌囊肿患者的胰腺癌发生率和特定病因死亡率的水平。

 

      为了完成本项研究,科学家对1999-2013年间被诊断为胰腺囊肿的美国退伍军人进行了回顾性队列研究。并使用美国癌症登记数据库和National Death Index(全国死亡记录集中数据库,包括特定原因的死亡率)确定了胰腺囊肿患者的胰腺癌的发病率和死亡率。

 

      研究结果显示在7211名患有胰腺囊肿的退伍军人中,研究人员总共随访31501人年(中位随访4.4年),其中79名(1.1%)在随访期间出现了胰腺癌。在研究随访期间,共有1982名患者(27.5%)死亡。六十三名患者(占死亡的3.2%;胰腺囊肿队列的0.9%)死于胰腺癌,但该队列中的主要死亡原因是非胰腺癌病因(n = 498,占死亡的25%)和血管疾病(n = 398,占死亡人数的20%)。

图:胰腺囊肿患者发生胰腺癌的几率

      本项研究证实在胰腺囊肿患者队列中,胰腺癌的发生率和与胰腺癌相关的死亡率非常低。大多数死亡是由非胰腺癌的原因和心血管原因引起的,只有一小部分(3.2%)可归因于胰腺癌。

 

 

 

原始出处:

Gobind S. Anand. Et al. Pancreas Cancer Incidence and Pancreas Cancer-Associated Mortality Are Low in National Cohort of 7211 Pancreas Cyst Patients. Digestive Diseases and Sciences.2021.

 

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Apr 06 09:12:39 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954089, encodeId=f9bd95408963, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/4e17700ebbac43d0a83b27157380f879/88a568d6b99c4089872c5383a4aec082.jpg, createdBy=e2635477181, createdName=ms3000000317925001, createdTime=Tue Apr 06 07:55:50 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954096, encodeId=1cec95409647, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/c0701935a2ce4be3b2674cc7a39fda3b/4cc95797da3b4488a48257e6ce67f6a0.jpg, createdBy=c0d15464145, createdName=ms9000001076948931, createdTime=Tue Apr 06 08:26:44 CST 2021, time=2021-04-06, status=1, ipAttribution=)]
    2021-05-13 ms6000001624652641

    学习

    0

  5. 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createdName=ms9000001076948931, createdTime=Tue Apr 06 08:26:44 CST 2021, time=2021-04-06, status=1, ipAttribution=)]
  6. 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createdName=ms9000001076948931, createdTime=Tue Apr 06 08:26:44 CST 2021, time=2021-04-06, status=1, ipAttribution=)]
  7. 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createdName=ms9000001076948931, createdTime=Tue Apr 06 08:26:44 CST 2021, time=2021-04-06, status=1, ipAttribution=)]
    2021-04-06 药师小王

    不错不错,写的很好

    0

  8. 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    2021-04-06 ms1000000928173667

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  9. 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  10. 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