Metabolism:减肥手术后孕妇、新生儿胰岛素抵抗和新生儿人体测量学指标

2019-05-07 xing.T 网络

由此可见,减肥手术后妊娠与母亲IR降低和新生儿体脂成分改变有关,出生体重和肥胖率显著降低,但脐带IR没有改善。

越来越多的女性在怀孕时已经接受了减肥手术,这是一种可持续减肥的流行治疗方法。近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,该研究的目的是调查减肥手术对孕产妇和新生儿胰岛素抵抗(IR)和新生儿体脂组成的影响。

在妊娠28周,研究人员对 41名减肥手术后孕妇和82名有类似的早孕期体重指数但没有减肥手术史的孕妇进行2小时75g口服葡萄糖耐量试验(OGTT)评估孕妇IR,通过脐带静脉血评估新生儿IR。在出生时,评估新生儿出生体重和体脂肪成分(通过测量皮肤皱褶计算)。使用IR稳态模型评估(HOMA-IR)评估胰岛素抵抗。

与无手术组相比,减肥手术组孕妇HOMA-IR(1.15 [1.04-2.07] vs. 2.20 [1.53-3.38]; p<0.01)、新生儿出生体重(p<0.01)和体脂( p<0.01)显著降低,而新生儿脐带HOMA-IR相似(1.29 [0.65-2.39] vs. 1.19 [0.46-1.93]; p=0.49)。在无手术组中,孕妇与新生儿HOMA-IR(p=0.03)和新生儿HOMA-IR与体脂(p<0.01)之间存在正相关。然而,在减肥手术组中没有检测到这种显著的相关性。 

由此可见,减肥手术后妊娠与母亲IR降低和新生儿体脂成分改变有关,出生体重和肥胖率显著降低,但脐带IR没有改善。 

原始出处:

Tanya Maric,et al.Maternal, neonatal insulin resistance and neonatal anthropometrics in pregnancies following bariatric surgery.Metabolism-Clinical and Experimental.2019.https://doi.org/10.1016/j.metabol.2019.04.005

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    2020-04-17 guojianrong
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    2019-06-08 一闲
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    2019-08-14 baoya
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    2019-05-09 闆锋旦
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    2019-05-07 CHANGE

    什么时候有懒人用的减肥神药?

    0

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