羟氯喹是酒渣鼻的新型治疗方法

2023-01-24 August MedSci原创 发表于上海

酒渣鼻是一种慢性面部炎症性疾病。据报道,羟氯喹(HCQ)是一种抗疟疾药物,具有抗炎活性。

酒渣鼻是一种慢性面部炎症性疾病。面部红斑、毛细血管扩张、丘疹/脓疱和反复潮红是该病的主要表型。酒渣鼻在不同人群中的患病率为2%-22%。虽然它不是一种致命的疾病,但由于中央面部的美容皮肤病,这显著降低了酒渣鼻患者的生活质量。尽管酒渣鼻的病理生理学很复杂,对它仍然知之甚少,但越来越多的研究认为免疫系统失调是酒渣鼻发病机制的关键因素。肥大细胞(MCs)通过诱导促炎因子的表达,包括IL-1β,TNF-α,IL-6,IL-17A,CCL2和CXCL2,是宿主防御的重要作用细胞。

羟氯喹(HCQ)目前常用于治疗全身性自身免疫性疾病患者,并被认为在妊娠期间是安全的。在这些疾病中,HCQ通过抑制免疫细胞功能和减少促炎细胞因子的分泌来充当免疫调节剂。此外,HCQ被认为通过抑制MC浸润,抑制血管生成和保护细胞免受UVB暴露起作用,这与酒渣鼻的发病机制有关。因此,这些证据表明HCQ可能是治疗酒渣鼻的潜在治疗方法。

HCQ治疗改善了小鼠的酒渣鼻样皮炎

在此项研究中,研究者揭示了HCQ改善酒渣鼻样小鼠和MCs中酒渣鼻的潜在分子机制。此外,还研究了HCQ治疗对酒渣鼻患者的影响。发现HCQ改善了酒渣鼻样表型和MCs浸润。HCQ治疗对酒渣鼻样小鼠的促炎因子和肥大细胞蛋白酶升高有显著抑制作用。在体外,HCQ抑制LL37诱导的MCs体外活化,包括炎症因子,趋化性,脱颗粒和钙内流的释放。此外,HCQ部分通过抑制KCa3.1介导的钙信号传导来减弱LL37介导的MCs激活。因此,这些证据表明HCQ改善酒渣鼻样皮炎可能是通过调节MC的免疫反应。最后,8周HCQ治疗对酒渣鼻患者的红斑和炎症病变发挥了满意的治疗效果,表明它是临床治疗中治疗酒渣鼻的有前景的药物。

口服200毫克HCQ,每日两次,持续8周,对患者有明显的治疗效果

总之,这些发现表明,HCQ抑制MC浸润和激活的治疗机制是通过KCa3.1介导的Ca2+信号传导,是临床治疗酒渣鼻的一种有前途的药物。然而,需要大规模的临床试验来进一步验证HCQ治疗酒渣鼻的安全性和有效性。

 

参考文献:

Li J, Yuan X, Tang Y, et al. Hydroxychloroquine is a novel therapeutic approach for rosacea. Int Immunopharmacol. 2020;79:106178. doi:10.1016/j.intimp.2019.106178.

 

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    2023-03-16 ms6000002119439055 来自山东省

    学习

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2120029, encodeId=c7d22120029bc, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3b66583064, createdName=ms6000002119439055, createdTime=Thu Mar 16 21:02:58 CST 2023, time=2023-03-16, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2119478, encodeId=377921194e832, content=停药后复发率高吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09356507185, createdName=ms4000000342898693, createdTime=Wed Mar 15 09:10:33 CST 2023, time=2023-03-15, status=1, ipAttribution=四川省), GetPortalCommentsPageByObjectIdResponse(id=2111339, encodeId=98102111339ff, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58475452253, createdName=佳佳子, createdTime=Tue Jan 24 20:40:03 CST 2023, time=2023-01-24, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=2111286, encodeId=7b81211128673, content=|学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Tue Jan 24 10:52:25 CST 2023, time=2023-01-24, status=1, ipAttribution=山东省)]
    2023-03-15 ms4000000342898693 来自四川省

    停药后复发率高吗?

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    2023-01-24 佳佳子 来自北京

    学习

    0

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    2023-01-24 八骏奔腾 来自山东省

    |学习

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