Diabetes Care:静息心率的危险因素及其与心血管疾病的关系

2021-03-03 MedSci原创 MedSci原创

强化降糖治疗与常规降糖治疗相比,仍与心率降低存在显著相关性。这与强化降糖治疗对CVD长期保护新疗效一致。治疗组对心率的影响的差异可以通过平均HbA1c的不同来进行解释。

与无糖尿病的个体相比,糖尿病患者的静息心率更高,这可能对长期血管疾病(CVD)风险具有预测价值。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员使用DCCT/EDIC研究的数据,评估了强化与常规降糖治疗对心率是否具有保护性效应,并评估了介导治疗组之间心率差异的因素以及心率对未来CVD风险的影响。

研究人员通过1402名1型糖尿病参与者22年随访期间的年度心电图的心率纵向变化进行了评估。线性混合模型用于评估治疗组对随时间推移变化的平均心率的影响,而Cox比例风险模型用于评估心率对CVD风险的影响。

52%的参与者为男性,平均年龄±SD为33±7岁,糖尿病病程为12±5年,强化与常规降糖治疗组的HbA1c分别为7.4±1.2%和9.1±1.6%。与常规降糖治疗组相比,强化降糖治疗组参与者的心率明显降低。尽管受试者心率的显著差异可以被平均HbA1c完全消除,但较高的心率可预测CVD和主要的不良心血管事件,而不受其他危险因素的影响。

由此可见,经过22年的随访,强化降糖治疗与常规降糖治疗相比,仍与心率降低存在显著相关性。这与强化降糖治疗对CVD长期保护新疗效一致。治疗组对心率的影响的差异可以通过平均HbA1c的不同来进行解释。
 
原始出处:
 
Sareh Keshavarzi,et al.Risk Factors for Longitudinal Resting Heart Rate and Its Associations With Cardiovascular Outcomes in the DCCT/EDIC Study.Diabetes care.2021.https://doi.org/10.2337/dc20-2387

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    2021-03-05 ms5000000518166734

    已读,受益匪浅

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1639719, encodeId=2d341639e19af, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Oct 12 19:13:58 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761581, encodeId=1d7f1e61581a9, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Feb 09 12:13:58 CST 2022, time=2022-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945707, encodeId=1a1e945e071b, content=已读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Fri Mar 05 13:02:37 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498836, encodeId=4f4c1498836cd, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Mar 05 09:13:58 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579033, encodeId=7b9615e903314, content=<a href='/topic/show?id=3007990e6f0' target=_blank style='color:#2F92EE;'>#静息心率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99076, encryptionId=3007990e6f0, topicName=静息心率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=692416492771, createdName=12498761m61暂无昵称, createdTime=Fri Mar 05 09:13:58 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902549, encodeId=cc2419025492a, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Jun 15 07:13:58 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945237, encodeId=22b794523ea5, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Mar 03 20:33:50 CST 2021, time=2021-03-03, status=1, ipAttribution=)]
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    2021-03-03 飞翔的乌龟

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