Stroke:房颤患者代谢综合征与缺血性卒中风险

2019-10-19 xing.T MedSci原创

由此可见,在调整CHA2DS2-VASc变量后,MetS的存在与缺血性卒中没有显著相关性。考虑MetS不太可能改善AF患者的卒中预测。

代谢综合症(MetS)是一种血栓形成前状态,与房颤(AF)和卒中的风险增加相关。CHA2DS2-VASc得分不能解释高血压前期、糖尿病前期、腹型肥胖、甘油三酯升高和低HDL(高密度脂蛋白)的MetS组分。在独立于CHA2DS2-VASc变量的AF患者中MetS与卒中之间的相关性数据有限。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在通过社区动脉粥样硬化风险(ARIC)研究确定与AF患者与缺血性卒中相关的MetS组分。

研究人员测量了纳入的1172名AF参与者5年内MetS组分。MetS由ATP标准和国际糖尿病联合会标准来定义。突发缺血性卒中由医师来裁决。研究人员采用多变量Cox比例风险回归分析来评估MetS成分与卒中之间的相关性。

中位随访14.8年后,共有113例缺血性卒中病例。在单个的MetS组分中,调整CHA2DS2-VASc变量后,低HDL与卒中风险增加相关(风险比为1.48[95%CI为0.99–2.21]),而其余MetS变量与卒中风险无关。调整CHA2DS2-VASc变量(风险比为1.38[95%CI为0.91-2.11])后,MetS组分超过3个与缺血性卒中无显著相关性。MetS每增加一个组分,卒中的风险就会增加13%;但是,这种关联具有临界意义(风险比为1.13[95%CI为0.99-1.28])。

由此可见,在调整CHA2DS2-VASc变量后,MetS的存在与缺血性卒中没有显著相关性。考虑MetS不太可能改善AF患者的卒中预测。 

原始出处:

Joseph J. Decker.et al.Metabolic Syndrome and Risk of Ischemic Stroke in Atrial Fibrillation ARIC Study.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.025376

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    2019-10-19 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2019-10-19 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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由此可见,东北地区的AF负担巨大,OAC治疗的未充分使用和合并症未能有效控制可能会在未来几十年中加剧AF患者的心血管结局。对于东北地区急需AF及相关危险因素长期管理的策略。

Europace:中国房颤注册研究全新分析:房颤消融成功3个月后或可安全停用口服抗凝药

近期,首都医科大学附属北京安贞医院马长生教授领衔的中国房颤注册登记研究组在Europace杂志上发表的一项最新研究结果表明,房颤患者如果既往没有缺血性中风、短暂性脑缺血发作、系统性血栓栓塞等病史,也不合并糖尿病,那么成功进行导管消融术后3个月时,可安全停用口服抗凝药物。

常喝小酒危害更大!韩国近千万人研究称:喝酒频率与房颤最相关

既往研究已经表明,重度饮酒是新发房颤的危险因素之一。可能有些人就会认为,只要不是每次狂饮烂醉,经常喝点小酒是没有关系的。然而,10月17日一项韩国977万余人的研究发现,经常喝小酒的房颤风险更高,明显大于不频繁的大酒。研究者指出,鉴于饮酒对健康的影响,相关指南都着重强调减少饮酒量,而不是喝酒频率。该研究说明,减少喝酒次数预防房颤最重要!分析显示,与每周喝两次酒的人相比,每天都喝酒的人新发房颤的风险

BMS和辉瑞宣布与Fitbit合作推动房颤可穿戴设备的及时诊断

百时美施贵宝(Bristol-Myers Squibb)和辉瑞(Pfizer)两家药业巨头宣布,他们正在与Fitbit结盟,以帮助推动及时诊断房颤(AFib)。