Stroke:产后期是脑静脉血栓形成的危险因素

2019-01-09 xing.T MedSci原创

由此可见,最近分娩的女性患CVT的风险增加,而怀孕期间CVT的风险似乎并未增加。

妊娠和产后期通常被认为是脑静脉血栓形成(CVT)的危险因素,但没有对照研究来量化风险。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,该病例对照研究使用来自5所教学医院连续就诊的成年CVT患者和来自荷兰MEGA研究(静脉血栓形成危险因素的多环境和遗传评估)的对照者数据。男性、50岁以上的女性、使用口服避孕药或最近人工流产或自发流产的女性被排除在外。研究人员根据患者的年龄和癌症病史进行了调整,并对产前和产后分层进行了调整,产后0至6周与产后7至12周进行了比较。

该研究共纳入了163/813例病例和1230/6296例对照者。患者较年轻(年龄中位数为38 vs. 41岁),并且通常有癌症史(14% vs. 4%),相比于对照者。总共有41/163(25%)例患者和82/1230(7%)对照者怀孕或处于产后期(调整后的比值比为3.8; 95%CI为2.4-6.0)。该关联完全归因于产后期间增加的CVT风险(调整后的比值比为10.6; 95%CI为5.6-20.0)。研究人员发现妊娠与CVT无关(调整后的比值比为1.2; 95%CI为0.6-2.3)。产后前6周内风险最高(调整后的比值比为18.7; 95%CI为8.3-41.9)。

由此可见,最近分娩的女性患CVT的风险增加,而怀孕期间CVT的风险似乎并未增加。

原始出处:

Suzanne M. Silvis.et al.Postpartum Period Is a Risk Factor for Cerebral Venous Thrombosis A Case-Control Study.Stroke.2018.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023017

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    2019-03-07 fusion
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    2019-06-01 xue8602
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