Medicine:流产会增加乳腺癌的发病风险?!NO!

2020-08-01 MedSci原创 MedSci原创

各种流行病学研究表明,流产与无配偶女性患乳腺癌的风险之间存在关联,但结果仍未定论。本荟萃分析在以往研究的基础上对其关联性进行了评估。

各种流行病学研究表明,流产与无配偶女性患乳腺癌的风险之间存在关联,但结果仍未定论。本荟萃分析在以往研究的基础上对其关联性进行了评估。

 

在2018年2月之前,对PubMed、EMBase、中国国家知识基础设施、重庆VIP和万方数据库进行了相关文章的检索。在这项荟萃分析中,使用固定效应模型来估计综合效应大小和相应的95%置信区间(CI)。所有统计数据均采用STATA 12.0进行分析。

 

本综述共纳入14篇文章,包括6篇队列研究和8篇病例对照研究。根据Newcastle Ottawa量表评估确定,所有文章都是高质量的。综合风险比(RR)显示,未生育女性中,人工流产和乳腺癌之间无显著关联(RR=1.023,95%CI=0.938-1.117;Z=0.51,P=.607)。亚组分析显示,未生育女性中,乳腺癌风险与人工流产之间或乳腺癌风险与自然流产(SA)之间没有显著关联(分别为RR = 1.008,95% CI = 0.909-1.118和RR = 1.062,95%CI = 0.902-1.250)。1次或>2次人工流产均不增加未生育女性乳腺癌的发病风险。敏感性分析表明,该研究的结果是可靠和稳定的。

 

总之,目前基于流行病学研究的证据显示,流产与未生育女性乳腺癌风险之间没有关联。

 

原始出处:

 

Huazhang TongYifan Wu, et al., No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis. Medicine (Baltimore). 2020 May;99(19):e20251. doi: 10.1097/MD.0000000000020251.

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    2020-10-27 kalseyzl
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    2021-05-19 jeanqiuqiu
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    2020-10-29 仁医06

    目前基于流行病学研究的证据显示,流产与未生育女性#乳腺癌#风险之间没有关联。

    0

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