治疗前列腺肥大竟可导致勃起功能障碍

2015-07-10 sunshine 译 MedSci原创

治疗前列腺肥大竟可导致勃起功能障碍患有良性前列腺肥大的男性,使用非那雄胺(也成为保列治或保法止)治疗可加重勃起功能障碍(ED)。此外,使用非那雄胺治疗前列腺肥大还可引起男性睾酮水平的下降导致男性性腺功能减退(没有性激素因此无法生育)。然而,使用坦索罗辛治疗前列腺肥大的男性却不存在这些问题。该研究由波士顿大学医学院领导进行,其研究结果在线发表于<激素分子生物学和临床研究杂志>。关于5α还

治疗前列腺肥大竟可导致勃起功能障碍




患有良性前列腺肥大的男性,使用非那雄胺(也成为保列治或保法止)治疗可加重勃起功能障碍(ED)。此外,使用非那雄胺治疗前列腺肥大还可引起男性睾酮水平的下降导致男性性腺功能减退(没有性激素因此无法生育)。然而,使用坦索罗辛治疗前列腺肥大的男性却不存在这些问题。

该研究由波士顿大学医学院领导进行,其研究结果在线发表于<激素分子生物学和临床研究杂志>。

关于5α还原酶抑制剂(5α-RIs)——如非那雄胺——严重且持久的副作用仍存在相当大的争议。许多研究者认为,对性功能的影响只是患者治疗时很小的一个副作用,而且由此引起的性功能障碍可通过后续的治疗解决。

研究人员调查研究了470名接受非那雄胺治疗以及230名接受α-受体阻滞剂坦索罗辛治疗的前列腺肥大患者。随访45个月,并对患者前列肥大症状的缓解情况进行评估,测定其前列腺特异性抗原以及睾酮的水平。采用老年男性症状量表评定药物对患者生活质量的影响,并采用国际勃起功能指数评定药物对患者勃起功能的影响。

结果发现,接受非那雄胺治疗的男性其勃起功能明显并且逐步下降,总睾酮水平也明显下降,而使用坦索罗辛治疗的男性并无这些表现。

这两种药物均已证明可有效治疗与前列腺肥大相关的下尿路症状。“然而,某些情况下5α 还原酶抑制剂可出现出持久的副作用,”该研究作者,波士顿大学医学院生化和泌尿科教授,Abdulmaged M. Traish博士解释道。“性功能是机体的一个重要组成部分,医生意识到此类药物对人体健康尤其是性功能的副作用这一点很重要。我们的研究强调,药物对勃起功能的影响是一个十分重要的问题,医生在用药时需要考虑的更仔细。”

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    2015-10-19 habb
  2. [GetPortalCommentsPageByObjectIdResponse(id=1771120, encodeId=6f7b1e7112060, content=<a href='/topic/show?id=c1c6334227d' target=_blank style='color:#2F92EE;'>#勃起#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33422, encryptionId=c1c6334227d, topicName=勃起)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78b838213583, createdName=habb, createdTime=Mon Oct 19 14:04:00 CST 2015, time=2015-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35216, encodeId=3bea3521677, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:26:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33602, encodeId=53713360257, content=哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=126b110623, createdName=ndd99, createdTime=Mon Jul 27 23:37:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32450, encodeId=f5463245028, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:38:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421021, encodeId=aaba142102178, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sun Jul 12 05:04:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502702, encodeId=32381502e02fc, content=<a href='/topic/show?id=bf0f3342395' target=_blank style='color:#2F92EE;'>#勃起功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33423, encryptionId=bf0f3342395, topicName=勃起功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e529549448, createdName=liuyiping, createdTime=Sun Jul 12 05:04:00 CST 2015, time=2015-07-12, status=1, ipAttribution=)]
    2015-08-07 hlycom3356

    期待有更多的研究

    0

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    2015-07-27 ndd99

    0

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    2015-07-12 huaxipanxing

    看看

    0

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