CELL:肿瘤诊断治疗新策略:代谢检测加饮食治疗

2020-06-19 MedSci原创 MedSci原创

肿瘤的转化与细胞代谢的深刻变化有关,但跟踪这些是否可以改善疾病分层或影响治疗决策,在很大程度上还是未知的。

肿瘤的转化与细胞代谢的深刻变化有关,但跟踪这些是否可以改善疾病分层或影响治疗决策,在很大程度上还是未知的。

最近,使用iKnife对烧灼标本的气溶胶进行采样,研究人员展示了一种新的实时诊断模式,将代谢表型与突变的PIK3CA基因型耦合。肿瘤性PIK3CA导致花生四烯酸的增加,并伴随着二十烷酸的过度生产,可促进细胞增殖,超越了细胞自主的方式。

在机制上,突变体PIK3CA驱动一个多模式信号网络,涉及mTORC2-PKCζ介导的钙依赖性磷脂酶A2(cPLA2)的激活。

值得注意的是,抑制cPLA2与无脂肪酸饮食协同作用,可以恢复免疫原性,并选择性地降低突变体PIK3CA诱导的肿瘤发生性。

除了凸显代谢表型在分层医学中的潜力外,该研究还揭示了激活的PI3K信号在调节花生四烯酸代谢中的重要作用,揭示了一种主要依赖于饮食脂肪限制的可靶向代谢脆弱性。

 

原始出处:

Nikos Koundouros et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids, CELL (2020). DOI:https://doi.org/10.1016/j.cell.2020.05.053

 

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    2021-04-30 维他命
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    2020-06-21 lqvr

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