JAMA:补充益生菌对老年人群抗生素使用率的影响

2020-07-08 MedSci原创 MedSci原创

每日补充鼠李糖乳杆菌GG和动物双歧杆菌BB-12不能显著减少老年人全因感染抗生素的使用量

近日研究人员考察了每日口服鼠李糖乳杆菌GG和动物双歧杆菌BB-12对居住在疗养院老年人群抗生素使用的影响。
 
研究在英国开展,2016年12月至2018年5月期间,310名65岁及以上的老年人参与,参与者随机每天服用一粒含有鼠李糖乳杆菌GG和动物双歧杆菌BB-12的胶囊(每粒胶囊的总菌数为1.3×1010 至1.6×1010)或安慰剂(n=155),随访1年,研究的主要终点为累积抗生素给药天数。
 
参与者平均年龄85.3岁,66.8%的女性,62.9%的参与者完成研究。益生菌组的参与者平均累积全身抗生素给药天数为12.9天,安慰剂组为12.0天(绝对差异为0.9天,调整后的风险比为1.13)。共有120名参与者经历了283例不良事件(益生菌组150例,安慰剂组133例)。益生菌组有94起事件发生,安慰剂组有78起事件发生,益生菌组死亡33起,安慰剂组32起。
 
研究认为,每日补充鼠李糖乳杆菌GG和动物双歧杆菌BB-12不能显著减少老年人全因感染抗生素的使用量。
 
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  2. [GetPortalCommentsPageByObjectIdResponse(id=1685168, encodeId=d9b4168516838, content=<a href='/topic/show?id=9bc05542024' target=_blank style='color:#2F92EE;'>#抗生素使用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55420, encryptionId=9bc05542024, topicName=抗生素使用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=765028091178, createdName=yangfl15, createdTime=Sat Feb 13 21:32:35 CST 2021, time=2021-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526764, encodeId=49d71526e64fc, content=<a href='/topic/show?id=f37e8012213' target=_blank style='color:#2F92EE;'>#老年人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80122, encryptionId=f37e8012213, topicName=老年人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615918, encodeId=1f631615918d5, content=<a href='/topic/show?id=158826812c4' target=_blank style='color:#2F92EE;'>#使用率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26812, encryptionId=158826812c4, topicName=使用率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8dee19693687, createdName=ms3830150583600765, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801788, encodeId=34b1801e88fd, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>益生菌也不能太神话了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Jul 08 23:37:20 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036159, encodeId=d4e5103615972, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Jul 08 21:32:35 CST 2020, time=2020-07-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1685168, encodeId=d9b4168516838, content=<a href='/topic/show?id=9bc05542024' target=_blank style='color:#2F92EE;'>#抗生素使用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55420, encryptionId=9bc05542024, topicName=抗生素使用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=765028091178, createdName=yangfl15, createdTime=Sat Feb 13 21:32:35 CST 2021, time=2021-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526764, encodeId=49d71526e64fc, content=<a href='/topic/show?id=f37e8012213' target=_blank style='color:#2F92EE;'>#老年人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80122, encryptionId=f37e8012213, topicName=老年人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615918, encodeId=1f631615918d5, content=<a href='/topic/show?id=158826812c4' target=_blank style='color:#2F92EE;'>#使用率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26812, encryptionId=158826812c4, topicName=使用率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8dee19693687, createdName=ms3830150583600765, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801788, encodeId=34b1801e88fd, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>益生菌也不能太神话了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Jul 08 23:37:20 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036159, encodeId=d4e5103615972, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Jul 08 21:32:35 CST 2020, time=2020-07-08, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1685168, encodeId=d9b4168516838, content=<a href='/topic/show?id=9bc05542024' target=_blank style='color:#2F92EE;'>#抗生素使用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55420, encryptionId=9bc05542024, topicName=抗生素使用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=765028091178, createdName=yangfl15, createdTime=Sat Feb 13 21:32:35 CST 2021, time=2021-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526764, encodeId=49d71526e64fc, content=<a href='/topic/show?id=f37e8012213' target=_blank style='color:#2F92EE;'>#老年人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80122, encryptionId=f37e8012213, topicName=老年人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615918, encodeId=1f631615918d5, content=<a href='/topic/show?id=158826812c4' target=_blank style='color:#2F92EE;'>#使用率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26812, encryptionId=158826812c4, topicName=使用率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8dee19693687, createdName=ms3830150583600765, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801788, encodeId=34b1801e88fd, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>益生菌也不能太神话了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Jul 08 23:37:20 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036159, encodeId=d4e5103615972, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Jul 08 21:32:35 CST 2020, time=2020-07-08, status=1, ipAttribution=)]
    2020-07-08 lovetcm

    #益生菌#益生菌也不能太神话了。

    1

    展开1条回复
  5. [GetPortalCommentsPageByObjectIdResponse(id=1685168, encodeId=d9b4168516838, content=<a href='/topic/show?id=9bc05542024' target=_blank style='color:#2F92EE;'>#抗生素使用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55420, encryptionId=9bc05542024, topicName=抗生素使用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=765028091178, createdName=yangfl15, createdTime=Sat Feb 13 21:32:35 CST 2021, time=2021-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526764, encodeId=49d71526e64fc, content=<a href='/topic/show?id=f37e8012213' target=_blank style='color:#2F92EE;'>#老年人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80122, encryptionId=f37e8012213, topicName=老年人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615918, encodeId=1f631615918d5, content=<a href='/topic/show?id=158826812c4' target=_blank style='color:#2F92EE;'>#使用率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26812, encryptionId=158826812c4, topicName=使用率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8dee19693687, createdName=ms3830150583600765, createdTime=Fri Jul 10 09:32:35 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801788, encodeId=34b1801e88fd, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>益生菌也不能太神话了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Jul 08 23:37:20 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036159, encodeId=d4e5103615972, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Jul 08 21:32:35 CST 2020, time=2020-07-08, status=1, ipAttribution=)]
    2020-07-08 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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