Exp Ther Med:2型先天淋巴细胞在过敏性鼻炎儿科患者中表达增加

2020-01-07 AlexYang MedSci原创

2型先天淋巴细胞(ILC2s)是一类新鉴定的先天免疫细胞。ILC2s能够通过Th2型细胞因子的分泌来促进过敏性气道疾病的特征,其中包括了白介素(IL)-4、IL-5和IL-13。而ILC2s是否在外周血中有积累仍旧未知。最近,有研究人员调查了ILC2s在儿科过敏性鼻炎(AR)患者中的水平以及与临床症状严重度的关系。研究包括了12名健康对照,12名对屋尘螨过敏(HDM-AR)的患者和18名对其他过敏

2型先天淋巴细胞(ILC2s)是一类新鉴定的先天免疫细胞。ILC2s能够通过Th2型细胞因子的分泌来促进过敏性气道疾病的特征,其中包括了白介素(IL)-4、IL-5和IL-13。而ILC2s是否在外周血中有积累仍旧未知。

最近,有研究人员调查了ILC2s在儿科过敏性鼻炎(AR)患者中的水平以及与临床症状严重度的关系。研究包括了12名健康对照,12名对屋尘螨过敏(HDM-AR)的患者和18名对其他过敏原单一过敏(不包括HDM)的患者(non-HDM-AR),并利用流式细胞仪检测了ILC2s的频率情况,并根据T5SS对AR临床症状进行了评估。研究发现,与健康对照相比,ILC2s在HDM-AR和非HDM-AR患者中的比例显著增加。AR患者的亚群分析表明了与非HDM-AR相比,ILC2s的比例在HMD-AR中显著增加。更多的是,ILC2水平和T5SS得分具有明显的关系。不考虑过敏原类型情况下,ILC2s频率在AR儿科患者的PBMC中显著增加。

最后,研究人员指出,HDM可能激发了更加严重的过敏反应,并增加了ILC2s的数量。他们的发现表明了ILC2在AR中的特殊功能,并提供了一个新的治疗靶标。

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