JCEM:循环中的microRNA-122水平和肝脏脂肪对减肥干预的反应

2022-01-22 MedSci原创 MedSci原创

对于减肥干预后循环microRNA-122(miR-122)和肝脏脂肪的变化之间的关系尚未明确。

对于减肥干预后循环microRNA-122(miR-122)和肝脏脂肪的变化之间的关系尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在探究18个月饮食和体育活动干预期间miR-122水平与肝脏脂肪含量变化之间的关联。

CENTRAL试验是一项在患有腹部肥胖或血脂异常的成年人中进行的为期18个月的随机对照试验。受试者被随机分配到低脂饮食或地中海/低碳水化合物饮食。在进行了为期六个月的饮食干预后,每个饮食组被进一步随机分为身体活动组或未进行身体活动组,并进行了12个月的干预。目前的研究纳入了220名基线参与者,134名参与者在18个月内重复测量了血清miR-122水平和肝脂肪含量。

血清miR-122水平从基线到18个月显著增加,而四个干预组之间没有观察到差异。研究人员发现miR-122水平与基线时肝脂肪含量之间存在显著关联,miR-122水平对数转换后每增加1个单位与肝脂肪含量高除3.79倍相关(P<0.001)。此外,研究人员发现较高的miR-122水平与18个月干预期间肝脂肪百分比的减少程度较少相关(β=1.56,P=0.002)。研究人员还发现miR-122水平和基线空腹血糖的变化与18个月内肝脏脂肪含量的变化之间存在显著的相互作用(相互作用P=0.02)。

由此可见,血清miR-122水平较高的参与者可能因饮食和体育活动干预而在减少肝脏脂肪含量方面受益较少。

原始出处:

Mengying Wang.et al.Circulating levels of microRNA-122 and hepatic fat change in response to weight-loss interventions: CENTRAL Trial.JCEM.2022.https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac023/6509072?redirectedFrom=fulltext

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    2022-04-08 仁者大医
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    2022-07-18 xjy02
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    2022-05-11 achengzhao
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    2022-01-24 zhouqu_8
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    2022-01-22 CHANGE

    什么时候有懒人用的减肥神药?

    0

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