Heart:心肌肌钙蛋白历史测量值识别心肌梗死高危患者

2022-08-11 MedSci原创 MedSci原创

hs-cTnT历史水平可用于入院hs-cTnT以改善急诊科就诊患者心肌梗死的早期风险分层。

在临床实践中使用高敏心肌肌钙蛋白 (hs-cTn) 检测提高对急诊科痛患者心肌梗死的早期诊断。欧洲心脏病学会(ESC)对疑似非ST段急性冠状动脉综合征(NSTE-ACS)患者治疗指南建议使用入院患者hs-cTnT浓度≥52 ng/L来识别心肌梗死高危人群,且确定需及时处理。许多出现胸痛的患者之前曾测量过高敏心肌肌钙蛋白T(hs-cTnT)水平,将这些测量结果纳入识别高风险心肌梗死患者的临床用途尚未明确。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员调查了历史hs-cTnT水平与入院hs-cTnT之间的相对变化是否可以改善对高风险心肌梗死患者的早期识别。

研究人员纳入了2009年12月至2016年12月期间在瑞典七个不同急诊科就诊的所有胸痛患者,这些患者在就诊时至少进行了一次hs-cTnT测量,并且至少获得了一次可用的测量数据。研究人员使用Logistic回归来探究使用当前和历史hs-cTnT测量值的各种组合在30天内诊断心肌梗死的诊断性能。

该研究共纳入了27809人次随访,其中30天内发生心肌梗死的人数达2686人(9.7%)。经入院hs-cTnT调整的hs-cTnT历史临界值与入院hs-cTnT≥52 ng/L的特异性(91.2%)相似,并且具有更高的阳性预测值,42.6%(95%CI为41.0%至44.3%) vs 38.9%(95%CI为37.4%至40.4%),以及更高的阳性似然比,6.95(95%CI为6.69至7.22)与5.95(95%CI为5.73至6.18)。在入院hs-cTnT<52 ng/L的患者中,结合hs-cTnT历史测量结果被归类为高危患者,28%的患者出现心肌梗死。

由此可见,hs-cTnT历史水平可用于入院hs-cTnT以改善急诊科就诊患者心肌梗死的早期风险分层。

原始出处:

Andreas Roos.et al.Using historical cardiac troponins to identify patients at a high risk of myocardial infarction.heart.2022.https://heart.bmj.com/content/early/2022/08/10/heartjnl-2022-321198

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    2022-08-13 zhaojie88
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    2022-08-13 cathymary
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    2022-08-13 slcumt

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