Nat Commun:代谢疾病的新型生物标记物猪胆酸被发现

2021-03-07 haibei MedSci原创

猪胆酸(Hyocholic acid,HCA)是一种对糖尿病表型自发发展具有特殊抵抗力的胆汁酸类型。HCA及其衍生物也存在于人类血液和尿液中。最近,研究人员研究了人类HCA谱是否可以预测代谢紊乱的发展

代谢相关的疾病,如肥胖、2型糖尿病(T2DM)、非酒精性脂肪性肝病(NAFLD)、中风和血管疾病(CVD),在人群中的发病率日益增高,其也成为最近几十年中临床和转化研究的关键领域。然而,由于个体间的差异性较大,用于这些代谢性疾病的早期检测和鉴别诊断的通用生物标志物十分有限。

猪胆酸(Hyocholic acid,HCA)是一种对糖尿病表型自发发展具有特殊抵抗力的胆汁酸类型。HCA及其衍生物也存在于人类血液和尿液中。最近,研究人员研究了人类HCA谱是否可以预测代谢紊乱的发展。

研究人员在第一个队列(n = 1107)中发现,肥胖和糖尿病都与较低的HCA物种的血清浓度有关。一个单独的队列研究(n = 91)验证了这一发现,并进一步揭示了糖尿病前期的个体与粪便中HCA物种的水平较低相关。

胃旁路手术后的患者(n = 38)血清HCA水平增加,可以预测手术后两年糖尿病的缓解情况。该结果在两个独立的前瞻性队列研究(n = 132和n = 207)中得到了验证,其发现血清HCA物种分别是5年和10年内代谢紊乱的有力预测因子。

这些发现强调了HCA物种与糖尿病的关联,并证明了利用HCA谱评估未来发生代谢异常风险的可行性。

 

原始出处:

Xiaojiao Zheng et al. Hyocholic acid species as novel biomarkers for metabolic disorders. Nature Communications (2021). 

 

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    2021-07-09 liye789132251
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    2021-08-22 wjywjy
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    2021-12-16 liuli5079
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    2021-03-09 muzishouyi
  8. [GetPortalCommentsPageByObjectIdResponse(id=1885037, encodeId=eb3a188503ebd, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jul 09 10:36:45 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904551, encodeId=781119045513d, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Sun Aug 22 11:36:45 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087946, encodeId=2c0a208e946df, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Thu Dec 16 16:36:45 CST 2021, time=2021-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345429, encodeId=4e1c134542949, content=<a href='/topic/show?id=8907693e0fa' target=_blank style='color:#2F92EE;'>#生物标记#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69370, encryptionId=8907693e0fa, topicName=生物标记)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=278f2500221, createdName=12498fa0m11暂无昵称, createdTime=Tue Mar 09 04:36:45 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349963, encodeId=1ccc134996365, content=<a href='/topic/show?id=3a59693e129' target=_blank style='color:#2F92EE;'>#生物标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69371, encryptionId=3a59693e129, topicName=生物标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Mar 09 04:36:45 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402016, encodeId=d3c81402016d3, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Tue Mar 09 04:36:45 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555323, encodeId=3109155532355, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Tue Mar 09 04:36:45 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946321, encodeId=cea0946321a5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=78f72514592, createdName=海1991, createdTime=Mon Mar 08 10:18:43 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946218, encodeId=463a946218d2, content=q, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210307/bf329a7b6e7147239f241d88429e94cd/a19a5ee461ce463fa6fffa78626f9e93.jpg, createdBy=52645466475, createdName=oYyzo, createdTime=Sun Mar 07 18:19:06 CST 2021, time=2021-03-07, status=1, ipAttribution=)]
    2021-03-08 海1991

    学习了

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    2021-03-07 oYyzo

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