J Clin Periodontol:超声心动图评估非手术牙周治疗对2型糖尿病患者心脏功能的影响

2020-05-31 网络 网络

炎症在心血管疾病的发病机制中起着重要的作用。糖尿病和牙周炎是高度流行的非传染性疾病,具有共同的危险因素。牙周炎会显着增加糖尿病患者的心血管和肾脏并发症的风险。

炎症在心血管疾病的发病机制中起着重要的作用。糖尿病和牙周炎是高度流行的非传染性疾病,具有共同的危险因素。牙周炎会显着增加糖尿病患者的心血管和肾脏并发症的风险。本临床试验研究了牙周治疗对患有牙周炎和2型糖尿病(T2DM)患者心脏功能的影响。

实验纳入58名患有牙周炎和T2DM的患者,随机分配给接受非手术牙周治疗的治疗组(n=29)和只接受口腔健康教育的对照组(n=29),对照组患者在为期6个月的实验结束后接受牙周治疗。利用超声心动图和组织多普勒成像指数(E/e'比率)评估左心室(LV)舒张功能,利用LV质量指数(LVMI)评估左室肥厚。采集血液样本进行生化分析。

结果发现,牙周治疗显着降低了E/e'比至1.66(95%CI:-2.64至-0.68,p<.01),并且牙周状况明显改善(p<.05)。在6个月的随访中,LVMI没有变化。血清心脏应激生物标志物NT-proBNP、C-反应蛋白和IL-6水平降低,但没有统计学意义。

因此,非手术牙周治疗可改善患有牙周炎的2型糖尿病患者的心脏舒张功能。

原文出处:

Yi Wang, A randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients,Journal of clinical periodontology, 2020 June,doi.org/10.1111/jcpe.13291

 

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    2020-06-01 misszhang

    谢谢MedSci提供最新的资讯

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