Eur Heart J:睡眠时间长短与12种心血管疾病之间的因果关系

2021-04-05 MedSci原创 MedSci原创

遗传预测的短睡眠时间是几种心血管疾病潜在的危险因素,而遗传预测的长睡眠时间不太可能是心血管疾病的因果性危险因素。

观察性研究结果表明,睡眠时间与许多血管疾病(CVDs)之间存在很强的相关性,但因果推论尚未得到证实。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在通过线性和非线性孟德尔随机化(MR)设计来明确遗传预测的睡眠时间和12种心血管疾病之间的因果关系。

研究人员对英国生物样本库中404044名参与者进行分析,利用与连续、短(≤6小时)和长(≥9小时)睡眠时间相关的遗传变异与12中心血管疾病的因果关系进行了评估。

线性MR分析显示,经多次校正后,遗传预测的睡眠时间与高血压、心房颤动、肺栓塞和慢性缺血性心脏病呈负相关(P<0.001)。非线性MR分析显示,遗传预测的睡眠时间与四种心血管病(包括高血压、慢性缺血性心脏病、冠状动脉疾病和心肌梗死)之间存在非线性关系(l型关联)。互补分析提供了确实的证据,表明遗传预测的短睡眠时间对12种CVD中的5种具有不良影响,包括高血压、肺栓塞、冠心病、心肌梗死和慢性缺血性心脏病(P<0.001),并发现其与房颤之间存在关系(P<0.05)。然而,遗传预测的长睡眠时间与任何心血管疾病无关。

这项研究表明,遗传预测的短睡眠时间是几种心血管疾病潜在的危险因素,而遗传预测的长睡眠时间不太可能是心血管疾病的因果性危险因素。

原始出处:

Sizhi Ai,et al.Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab170

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    2021-04-07 zhaojie88
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    2021-04-07 slcumt
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    2021-04-06 ms5000000518166734

    已读,真是触目惊心呀!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1357680, encodeId=35f7135e680da, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498854, encodeId=5b5a1498854a7, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563437, encodeId=850a156343e95, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954293, encodeId=818595429314, content=已读,真是触目惊心呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Apr 06 19:58:42 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954276, encodeId=4dc19542e607, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/fa40a94553954d3f80b32581c711e8a5/5936b12f6e2c493eaa2f32fdac478e27.jpg, createdBy=6ffe5477440, createdName=开心预备队员, createdTime=Tue Apr 06 18:59:08 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954119, encodeId=d86a95411932, content=什么是遗传预测的睡眠时间?<a href='/topic/show?id=c03f104228df' target=_blank style='color:#2F92EE;'>#睡眠时间与心血管疾病#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104228, encryptionId=c03f104228df, topicName=睡眠时间与心血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/894c67401e154c6e8ef0a5d7fe76a475/67b9d73f386a432db7e534f6b37a53db.JPG, createdBy=e20c5203087, createdName=akuan3606, createdTime=Tue Apr 06 09:30:19 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954064, encodeId=8c69954064c9, content=可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/c0701935a2ce4be3b2674cc7a39fda3b/4cc95797da3b4488a48257e6ce67f6a0.jpg, createdBy=c0d15464145, createdName=ms9000001076948931, createdTime=Mon Apr 05 23:11:16 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954043, encodeId=aafa9540431c, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Apr 05 22:01:58 CST 2021, time=2021-04-05, status=1, ipAttribution=)]
    2021-04-06 开心预备队员

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1357680, encodeId=35f7135e680da, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498854, encodeId=5b5a1498854a7, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563437, encodeId=850a156343e95, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954293, encodeId=818595429314, content=已读,真是触目惊心呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Apr 06 19:58:42 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954276, encodeId=4dc19542e607, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/fa40a94553954d3f80b32581c711e8a5/5936b12f6e2c493eaa2f32fdac478e27.jpg, createdBy=6ffe5477440, createdName=开心预备队员, createdTime=Tue Apr 06 18:59:08 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954119, encodeId=d86a95411932, content=什么是遗传预测的睡眠时间?<a href='/topic/show?id=c03f104228df' target=_blank style='color:#2F92EE;'>#睡眠时间与心血管疾病#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104228, encryptionId=c03f104228df, topicName=睡眠时间与心血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/894c67401e154c6e8ef0a5d7fe76a475/67b9d73f386a432db7e534f6b37a53db.JPG, createdBy=e20c5203087, createdName=akuan3606, createdTime=Tue Apr 06 09:30:19 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954064, encodeId=8c69954064c9, content=可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/c0701935a2ce4be3b2674cc7a39fda3b/4cc95797da3b4488a48257e6ce67f6a0.jpg, createdBy=c0d15464145, createdName=ms9000001076948931, createdTime=Mon Apr 05 23:11:16 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954043, encodeId=aafa9540431c, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Apr 05 22:01:58 CST 2021, time=2021-04-05, status=1, ipAttribution=)]
    2021-04-06 akuan3606

    什么是遗传预测的睡眠时间?#睡眠时间与心血管疾病#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1357680, encodeId=35f7135e680da, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498854, encodeId=5b5a1498854a7, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563437, encodeId=850a156343e95, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954293, encodeId=818595429314, content=已读,真是触目惊心呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Apr 06 19:58:42 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954276, encodeId=4dc19542e607, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/fa40a94553954d3f80b32581c711e8a5/5936b12f6e2c493eaa2f32fdac478e27.jpg, createdBy=6ffe5477440, createdName=开心预备队员, createdTime=Tue Apr 06 18:59:08 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954119, encodeId=d86a95411932, content=什么是遗传预测的睡眠时间?<a href='/topic/show?id=c03f104228df' target=_blank style='color:#2F92EE;'>#睡眠时间与心血管疾病#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104228, encryptionId=c03f104228df, topicName=睡眠时间与心血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/894c67401e154c6e8ef0a5d7fe76a475/67b9d73f386a432db7e534f6b37a53db.JPG, createdBy=e20c5203087, createdName=akuan3606, createdTime=Tue Apr 06 09:30:19 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954064, encodeId=8c69954064c9, content=可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/c0701935a2ce4be3b2674cc7a39fda3b/4cc95797da3b4488a48257e6ce67f6a0.jpg, createdBy=c0d15464145, createdName=ms9000001076948931, createdTime=Mon Apr 05 23:11:16 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954043, encodeId=aafa9540431c, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Apr 05 22:01:58 CST 2021, time=2021-04-05, status=1, ipAttribution=)]
    2021-04-05 ms9000001076948931

    可以

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1357680, encodeId=35f7135e680da, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498854, encodeId=5b5a1498854a7, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563437, encodeId=850a156343e95, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Apr 07 11:28:41 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954293, encodeId=818595429314, content=已读,真是触目惊心呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Apr 06 19:58:42 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954276, encodeId=4dc19542e607, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/fa40a94553954d3f80b32581c711e8a5/5936b12f6e2c493eaa2f32fdac478e27.jpg, createdBy=6ffe5477440, createdName=开心预备队员, createdTime=Tue Apr 06 18:59:08 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954119, encodeId=d86a95411932, content=什么是遗传预测的睡眠时间?<a href='/topic/show?id=c03f104228df' target=_blank style='color:#2F92EE;'>#睡眠时间与心血管疾病#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104228, encryptionId=c03f104228df, topicName=睡眠时间与心血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210406/894c67401e154c6e8ef0a5d7fe76a475/67b9d73f386a432db7e534f6b37a53db.JPG, createdBy=e20c5203087, createdName=akuan3606, createdTime=Tue Apr 06 09:30:19 CST 2021, time=2021-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954064, encodeId=8c69954064c9, content=可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/c0701935a2ce4be3b2674cc7a39fda3b/4cc95797da3b4488a48257e6ce67f6a0.jpg, createdBy=c0d15464145, createdName=ms9000001076948931, createdTime=Mon Apr 05 23:11:16 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954043, encodeId=aafa9540431c, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Apr 05 22:01:58 CST 2021, time=2021-04-05, status=1, ipAttribution=)]
    2021-04-05 wxl882001

    了解

    0

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