Stroke:缺血性脑卒中后吞咽功能障碍还能恢复吗?

2020-03-27 shaosai MedSci原创

本研究旨在验证脑卒中后吞咽困难远期功能恢复的临床和影像学指标,利用机器学习建立和验证预测模型。

背景和目的

本研究旨在验证脑卒中后吞咽困难远期功能恢复的临床和影像学指标,利用机器学习建立和验证预测模型。

方法

本研究共纳入了137 行吞咽检查的急性缺血性脑卒中的患者。对有吞咽困难的患者进行随访6个月,利用方法和Cox回归分析模型评价临床和影像学指标。利用预测指标建立Bayesian网络模型来对患者进行分类,良好吞咽功能(不需要管饲或调整饮食6个月)和较差吞咽功能(需要管饲或调整饮食6个月)。

结果

共有24例患者在随访的6个月中出现持续的吞咽困难,平均为65.6天。脑卒中后吞咽困难时间会因为管饲状态、临床吞咽困难评分、性别、严重脑白质异常高信号和放射冠、基底节或内囊共存双侧病变具有显著性差别。Cox回归分析模型多元分析表明,在这些影响指标中,管饲状态(P<0.001)、CR/BG/IC共存双侧病变(P=0.001)和临床吞咽困难评分(P=0.042)是与预后具有显著性相关的指标。在tree-augmented网络分类器中,基于10个指标(性别、CR/BG/IC/内囊病变、偏侧化、脑干前外侧、CR/BG/IC双侧病变、严重白质异常高信号、临床吞咽困难评分和管饲状态)的预测效果要由于其他基准分类器。

结论

基线吞咽困难严重程度、CT/BG/IC双侧病变与6个月吞咽功能恢复具有良好的预测价值。基于临床和影像学指标所建立的Bayesian网络模型能够成功预测6个月吞咽功能恢复情况。以双侧皮层下白质病变作为预测指标可作为预测长期吞咽功能恢复的指标。

原始出处:

Lee WH 1, Lim MH 1, Seo HG.et al. Development of a Novel Prognostic Model to Predict 6-Month Swallowing Recovery After Ischemic Stroke.DOI:10.1161/STROKEAHA.119.027439

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    2020-03-27 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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高分辨血管壁磁共振成像能够显示颈动脉斑块形态特点和成分。有许多研究利用2D颈动脉斑块成像技术来评价颈动脉斑块,纵向范围大约为30mm,这对完整显示颅外颈动脉斑块尚不充分。

Stroke:用PET评估颈动脉狭窄患者复发性脑卒中的风险!

在症状性颈动脉内膜剥脱术随机试验中,仅有中度狭窄的患者可能从中获益,有些重度狭窄的患者从中并无法获益。颈动脉斑块18F-氟脱氧葡萄糖PET能够反映斑块炎症反应,能够预测复发性脑卒中。

Neurology:静脉溶栓前双抗预治疗的结局

来自美国的 Konark Malhotra 等在 Neurology 上公布了他们的系统性综述和 meta 分析结果,目的在于评价具有 DAPP 病史的急性缺血性卒中患者采取 IVT 的安全性和有效性

Stoke:CT灌注成像在脑卒中合并心功能受损中的应用

左心室射血分数(LVEF)减低会加重脑卒中后预后。本研究旨在验证灌注计算机体层成像中的动脉输入函数(AIF),尤其是扫描开始至AIF结束(SO-EndAIF)时间能够反映心输出量减少。

Stroke:青少年脑卒中患者局灶性脑动脉病

局灶性脑动脉病是一种年轻人动脉缺血性卒中罕见的病因。随访颅内成像检查对鉴别进展性动脉病变至关重要。

Stroke:深度学习在脑卒中患者中检出半暗带组织的价值

急性缺血性脑卒中介入治疗患者的选择主要依赖于动态磁敏感对比磁共振成像(DSC-MRI)或计算机体层灌注成像(CTP)。动态磁敏感对比磁共振成像需要注射对比剂才能完成检查,而计算机体层成像灌注又会产生高