Int J Urol:前列腺癌患者中,精囊液中的睾酮与血清睾酮哪个是衡量勃起功能更好的指标?

2022-07-04 AlexYang MedSci原创

调查了精囊液中可能影响勃起功能的因素。

精液中含有由男性生殖器官分泌的组织特异性蛋白,且包括前列腺液和精囊液,其中精囊液所占比例最大(约65%)。精囊液对精液凝固、精子染色质稳定和精子运动能力非常重要。精囊液中含有各种因子,如前列腺素E2(PGE2)、锌和睾酮。这些物质对精子的运动能力具有重要作用。然而,这些因素是否影响勃起功能尚不清楚。

近期,来自日本的研究人员在《Int J Urol》上发表文章,他们调查了精囊液中可能影响勃起功能的因素

研究人员在获得机构审查委员会批准后,收集了134名接受机器人辅助根治性前列腺切除术的局部前列腺癌患者的精囊液样本。调查了男性性健康问卷(SHIM)结果、勃起硬度评分、关于有无性欲的问卷、精囊液中一些因子(睾酮、PGE2、转化生长因子β1和8-羟基-2-脱氧鸟苷)的浓度以及血清睾酮水平之间的关系。

研究中,参与者的中位年龄为67岁(范围51-77岁)。研究样本中位浓度为:精囊睾酮1.85(范围0.17-4.32)纳克/毫升,血清睾酮4.60(范围1.75-10.82)纳克/毫升。在SHIM评分≥17的参与者中,精囊睾酮浓度显著增加(P=0.002),而血清睾酮水平没有明显差异(P=0.661)。多变量分析显示,精囊睾酮与SHIM评分显著相关(≥17 vs. <17;几率比2.137,95%置信区间1.148-3.978,p=0.016)。

患者特征的单变量和多变量分析

综上所述,精囊液中的睾酮水平可以反映前列腺癌患者的勃起功能,表明精囊中的睾酮对男性勃起功能非常重要

 

原始出处:

Eiji Kashiwagi, Masaki Shiota, Hidekazu Naganuma et al. Testosterone level in seminal vesicle fluid is a better indicator of erectile function than serum testosterone in patients with prostate cancer. Int J Urol. Jun 2022.

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    2022-10-13 habb
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