Mayo Clin Proc:富含血小板血浆对慢性伤口愈合的疗效和安全性

2021-10-20 MedSci原创 MedSci原创

慢性伤口是常见的慢性病之一,对老龄人口的影响很大,为患者接社会带来较大的经济负担。最常见的与伤口形成有关的疾病包括糖尿病和压力性损伤。目前的治疗方法主要是治疗潜在的疾病和做好伤口护理,以促进健康的肉芽

慢性伤口是常见的慢性病之一,对老龄人口的影响很大,为患者接社会带来较大的经济负担。最常见的与伤口形成有关的疾病包括糖尿病和压力性损伤。目前的治疗方法主要是治疗潜在的疾病和做好伤口护理,以促进健康的肉芽组织生长。新的治疗方式旨在优化微环境,除了标准护理外,还应用生长因子,如血小板衍生的生长因子,以便诱导或加速慢性伤口的愈合过程。近日,一项发表于Mayo Clin Proc的新的系统回顾评估了自体富血小板血浆(PRP)对下肢糖尿病溃疡、下肢静脉溃疡和压疮患者的有效性和不良反应。

研究人员搜索了从数据库开始到2020年6月11日的多个数据库,检索比较PRP与其他任何不含PRP的伤口护理的随机对照试验和观察性研究,患者人群为下肢糖尿病溃疡、下肢静脉溃疡和压疮的成年人。

研究共纳入了20项随机对照试验和5项观察性研究。分析结果显示,与不使用PRP的管理相比,PRP治疗明显增加了下肢糖尿病溃疡的伤口完全愈合(相对风险,1.20;95% CI,1.09-1.32,中等证据强度[SOE]),缩短了伤口完全愈合的时间,并减少了伤口面积和深度(低SOE)。在伤口感染、截肢、伤口复发或住院方面没有发现明显变化。在下肢静脉溃疡或压力溃疡患者中,SOE不足以评估对关键结果的影响,如伤口完全愈合或伤口完全愈合的时间。在不良事件方面没有统计学上的显著差异。

综上所述,该研究结果表明,自体PRP可以增加伤口完全愈合,缩短愈合时间,并减少下肢糖尿病溃疡患者的伤口大小。但是,目前的证据不足以评估其对下肢静脉溃疡或压力溃疡患者的伤口愈合的影响。

原始出处:

Wenchun Qu, et al., The Effectiveness and Safety of Platelet-Rich Plasma for Chronic Wounds: A Systematic Review and Meta-analysis. Mayo Clin Proc. 2021 Sep;96(9):2407-2417. doi: 10.1016/j.mayocp.2021.01.030. 

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    2022-09-26 heli0118
  5. [GetPortalCommentsPageByObjectIdResponse(id=1743771, encodeId=4a8d1e437710b, content=<a href='/topic/show?id=6d40534e088' target=_blank style='color:#2F92EE;'>#慢性伤口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53470, encryptionId=6d40534e088, topicName=慢性伤口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7f2735217910, createdName=drwjr, createdTime=Fri Jun 03 04:13:01 CST 2022, time=2022-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811957, encodeId=6628181195e69, content=<a href='/topic/show?id=5ab78905623' target=_blank style='color:#2F92EE;'>#血小板血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89056, encryptionId=5ab78905623, topicName=血小板血浆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Tue Jun 28 17:13:01 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721096, encodeId=bae71e2109637, content=<a href='/topic/show?id=634ee040179' target=_blank style='color:#2F92EE;'>#疗效和安全性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70401, encryptionId=634ee040179, topicName=疗效和安全性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ef32982072, createdName=经常头晕, createdTime=Sun Sep 04 21:13:01 CST 2022, time=2022-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977041, encodeId=fdfd19e70415b, content=<a href='/topic/show?id=b9f11560065' target=_blank style='color:#2F92EE;'>#ROC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15600, encryptionId=b9f11560065, topicName=ROC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Sep 26 00:13:01 CST 2022, time=2022-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1069540, encodeId=79fc1069540e4, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Fri Nov 12 10:37:53 CST 2021, time=2021-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309916, encodeId=0f9c1309916ed, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Oct 22 12:13:01 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602396, encodeId=f2b71602396d3, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Oct 22 12:13:01 CST 2021, time=2021-10-22, status=1, ipAttribution=)]
    2021-11-12 湘雅科教

    已拜读,受益匪浅。

    0

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