JACC:无聚合物和耐用型聚合物药物洗脱支架的远期预后比较

2020-07-10 MedSci原创 MedSci原创

在随机临床试验中,对使用药物洗脱支架(DES)治疗的冠心病患者进行长期长期随访后的结果数据很少。本研究的目的旨在评估ISAR-TEST-5临床试验中患者的10年随访结果。

在随机临床试验中,对使用药物洗脱支架(DES)治疗的冠心病患者进行长期长期随访后的结果数据很少。本研究的目的旨在评估ISAR-TEST-5临床试验中患者的10年随访结果。

本研究将3002例患者被随机分为无聚合物西罗莫司或普罗布考洗脱支架(n=2002)或耐用型聚合物佐他莫司洗脱支架(n=1000)。主要终点是心源性死亡、靶血管相关心肌梗死或靶病变血运重建的复合事件。患者入组时的平均年龄为67.8岁,随访10年后,63.9%的患者存活。主要终点事件发生率在两组患者之间无明显差异(43.8% vs. 43.0%,p=0.90)。两组复合终点的单个成分的比率也无明显差异。另外,10年以上明确/可能发生支架血栓的发生率较低,两组之间无明显差异。

研究结果显示,无聚合物药物组与耐用聚合物药物洗脱支架组的疗效在10年后无显着差异。支架内血栓发生率低,且在两组患者间无明显差异。

原始出处:

Sebastian K et al.10-Year Outcomes From a Randomized Trial of Polymer-Free Versus Durable Polymer Drug-Eluting Coronary Stents.JACC.2020 July.

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    2021-04-17 hbwxf
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    2020-07-12 yese

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