PLoS One:降压/降脂复合制剂降低卒中和心脏病风险

2012-07-23 刘卓 新华网

   英国伦敦大学玛丽女王学院的研究人员在新一期PLoS One(《科学公共图书馆综合卷》)杂志上报告说,他们将氨氯地平、氯沙坦、氢氯噻嗪这三种降压药物和辛伐他汀这种降胆固醇药物混合在一起制成复合制剂,并以80多名50岁以上的中老年人为对象进行了随机对比试验。        结果显示,这种复合制剂可以使服药者血压平均降低12

   英国伦敦大学玛丽女王学院的研究人员在新一期PLoS One(《科学公共图书馆综合卷》)杂志上报告说,他们将氨氯地平、氯沙坦、氢氯噻嗪这三种降压药物和辛伐他汀这种降胆固醇药物混合在一起制成复合制剂,并以80多名50岁以上的中老年人为对象进行了随机对比试验。

       结果显示,这种复合制剂可以使服药者血压平均降低12%,体内有害胆固醇含量平均降低39%。高血压和高胆固醇是导致中老年人患卒中和心脏病的重要原因。

       研究人员认为,50岁以上的人服用这种复合制剂可以大大降低患卒中和心脏病风险,其好处可以折算为平均延长寿命11年。据估算,英国即使只有一半50岁以上的人服用这种制剂,每年也可以避免超过9万起卒中和心脏病发作病例。
 
链接:Wald DS,Morris JK,Wald NJ.Randomized Polypill Crossover Trial in People Aged 50 and  Over.PLoS One 2012;7(7):e41297.

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