JCEM:胰岛素样生长因子-1、骨密度和骨折的关系

2021-01-20 MedSci原创 MedSci原创

该研究的结果支持IGF-1对骨折具有预防作用,可能并部分是由更高的骨密度所介导。

在观察性研究中,循环胰岛素样生长因子-1 (IGF-1)水平与骨密度和骨折风险的相关性尚未明确。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员进行了一项孟德尔随机化研究以评估血清IGF-1水平与的骨密度(eBMD)和骨折之间的关系。

研究人员从包括358072名欧洲血统受试者的全基因组相关性研究中选择了全基因组显著性水平(P<5×10-8)的IGF-1基因工具。eBMD(426824名受试者)和骨折(53184例骨折病例和373611例非骨折病例)的汇总数据来自英国生物样本库研究。研究人员使用单变量和多变量孟德尔随机化分析方法来评估IGF-1与eBMD和骨折之间的相关性。该研究的主要结局包括基因预测血清IGF-1水平升高1个SD对应的eBMD变化和骨折比值比。

当IGF-1水平升高1个SD时,eBMD水平变化为0.04 g/cm2 (95%CI为0.01-0.07;P=0.011),骨折比值比为0.94 (95%CI为0.91-0.98;P=0.003)。在对身高进行调整后,这种相关性仍然存在,且幅度相似。在排除可能直接影响这些结果的遗传因素后,其与骨折的相关性保持一致,但与eBMD之间的相关性则不一致。调整eBMD后,IGF-1与骨折的相关性有所减弱(比值比为0.96;95%置信区间为0.92-0.99;P=0.012)。

由此可见,该研究的结果支持IGF-1对骨折具有预防作用,可能并部分是由更高的骨密度所介导。

原始出处:

Shuai Yuan.et al.Insulin-like Growth Factor-1, Bone Mineral Density, and Fracture: A Mendelian Randomization Study.JCEM.2021.https://doi.org/10.1210/clinem/dgaa963

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    2021-06-03 smallant2015
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    2021-09-14 achengzhao
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    2021-09-20 baoya
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    2021-01-21 医鸣惊人

    认真学习了

    0

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