JAHA:QT间期动态变化与心血管结局

2021-09-28 MedSci原创 MedSci原创

使用来自连续心电图检查的纵向信息可以提高对CVD结局的预测能力。与线性斜率或均方根误差相比,校正的长期平均QT与CVD结局的相关性更强。这一新证据具有临床意义,因为心电图经常使用、无创且价格低廉。

长QT与室性心律失常血管疾病(CVD)死亡率和心源性猝死相关。然而,迄今为止,还没有研究调查真实世界中不同个体QT随时间变化的动态与CVD事件和全因死亡风险之间的关系。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,这项针对北加州综合医疗保健提供系统成员的队列研究,包括61455名受试者(平均年龄为62岁;60%为女性,42%为非白人),具有3次或以上心电图检查结果(2005-2009年为基线;平均值±SD随访时间为7.6±2.6年)。

在完全调整的模型中,第3三分位数与第1三分位数相比,平均QT校正(使用Fridericia校正)与心脏骤停(风险比[HR]为1.66)、心力衰竭(HR为1.62)、室性心律失常(HR为1.56)相关、所有CVD(HR为1.31)、缺血性心脏病(HR为1.28)、总卒中(HR为1.18)和全因死亡率(HR为1.24)。

第3个三分位数与第2个三分位数相比,QT校正线性斜率与心脏骤停(HR为1.22)、室性心律失常(HR为1.12)和全因死亡率(HR为1.09)相关。第3个三分位数与第1个三分位数相比,QT校正的均方根误差与室性心律失常(HR为1.34)、心力衰竭(HR为1.28)、全因死亡率(HR为1.20)、所有CVD(HR为1.14)、总卒中(HR为1.08)和缺血性心脏病(HR为1.07)相关。

该研究的结果表明,使用来自连续心电图检查的纵向信息可以提高对CVD结局的预测能力。与线性斜率或均方根误差相比,校正的长期平均QT与CVD结局的相关性更强。这一新证据具有临床意义,因为心电图经常使用、无创且价格低廉。

原始出处:

Neha Mantri.et al.QT Interval Dynamics and Cardiovascular Outcomes: A Cohort Study in an Integrated Health Care Delivery System.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.018513

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    2021-09-30 zhaohui6731
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    2021-09-30 xinmeili

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