Int Arch Allergy Immunol:鼻内镜在过敏性鼻炎和屋尘螨舌下免疫疗法中的作用

2021-06-09 AlexYang MedSci原创

在过去的30年里,舌下免疫疗法(SLIT)被广泛认为是治疗过敏性鼻炎(AR)的一种安全有效的治疗方式,能够改变过敏性疾病的自然进程。在评估SLIT疗效的众多方法中,主观评估,如鼻部症状总分(TNSS)

在过去的30年里,舌下免疫疗法(SLIT)被广泛认为是治疗过敏性鼻炎(AR)的一种安全有效的治疗方式,能够改变过敏性疾病的自然进程。在评估SLIT疗效的众多方法中,主观评估,如鼻部症状总分(TNSS)、药物总分(TMS)和视觉模拟量表(VAS)在临床研究中普遍使用。尽管它们频繁使用,然而这些评估在很大程度上取决于患者的感知,缺乏辅助的客观结果。

虽然有相当多的证据表明舌下免疫疗法(SLIT)的疗效,但对过敏性鼻炎(AR)患者的鼻部症状的改善情况仍不清楚。近期,有研究人员通过内窥镜检查和改良的Lund-Kennedy(MLK)评分系统描述和评估了SLIT的治疗效果

研究共纳入了105名屋尘螨AR患者,并使用标准化的Dermatophagoides farinae(D. farinae)滴剂治疗1年。在基线时间点和6、12个月时评估了鼻部症状总分(TNSS)、药物治疗总分(TMS)、视觉模拟量表(VAS)和MLK得分。还比较了MLK得分与TNSS、TMS和VAS的相关性。

结果发现,与基线相比,SLIT治疗后的TNSS、TMS和VAS评分均有统计学意义上的下降(所有P<0.05)。治疗12个月后,良好控制、部分控制和未控制的AR患者比例分别为42%、49.5%和8.5%。鼻内镜检查结果显示鼻部体征有明显改善,主要包括鼻甲粘膜颜色改变、鼻腔分泌物减少和鼻腔水肿的改善。另外,MLK评分明显下降,而且MLK和VAS评分之间存在正相关关系。

MLK评分与TNSS、TMS和VAS之间的关系

综上所述,除了常用的主观评估(TMS、TNSS和VAS)外,他们的内窥镜检查结果和MLK评分一致证实了SLIT是AR患者的有效治疗方式。在临床实践和结果研究中,MLK评分可作为评估SLIT疗效的一个辅助工具。

原始出处:

Beina Liu, Jiapeng Feng, Sunhong Hu. The Role of Nasal Endoscopy in Allergic Rhinitis and House Dust Mite Sublingual Immunotherapy. Int Arch Allergy Immunol. May 2021

 

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    2021-08-23 zhs3882
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    2021-06-11 膀胱癌
  5. [GetPortalCommentsPageByObjectIdResponse(id=2016490, encodeId=d5fc201649032, content=<a href='/topic/show?id=6324103414a3' target=_blank style='color:#2F92EE;'>#鼻内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103414, encryptionId=6324103414a3, topicName=鼻内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Mon Aug 23 21:53:47 CST 2021, time=2021-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047418, encodeId=f80e204e4186a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Feb 12 20:53:47 CST 2022, time=2022-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262242, encodeId=2aa71262242cb, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329511, encodeId=a5b81329511bc, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348603, encodeId=bef8134860338, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972520, encodeId=7c979e252038, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/KbC410CniaDHx422zeY8c54ibCJOFj7oBa6J9nvp1TeRiaWuVGbWdu6PUW4bwnfs1umZVdvYU9JLvXuXqf37EdWIQ/132, createdBy=54672480577, createdName=zsq101, createdTime=Thu Jun 10 15:25:18 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972181, encodeId=47e79e218199, content=这样子啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b41d5175461, createdName=学习蜗牛, createdTime=Wed Jun 09 16:35:07 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972166, encodeId=944b9e21667b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=119b1409956, createdName=784699923, createdTime=Wed Jun 09 15:52:21 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2016490, encodeId=d5fc201649032, content=<a href='/topic/show?id=6324103414a3' target=_blank style='color:#2F92EE;'>#鼻内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103414, encryptionId=6324103414a3, topicName=鼻内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Mon Aug 23 21:53:47 CST 2021, time=2021-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047418, encodeId=f80e204e4186a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Feb 12 20:53:47 CST 2022, time=2022-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262242, encodeId=2aa71262242cb, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329511, encodeId=a5b81329511bc, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348603, encodeId=bef8134860338, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972520, encodeId=7c979e252038, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/KbC410CniaDHx422zeY8c54ibCJOFj7oBa6J9nvp1TeRiaWuVGbWdu6PUW4bwnfs1umZVdvYU9JLvXuXqf37EdWIQ/132, createdBy=54672480577, createdName=zsq101, createdTime=Thu Jun 10 15:25:18 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972181, encodeId=47e79e218199, content=这样子啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b41d5175461, createdName=学习蜗牛, createdTime=Wed Jun 09 16:35:07 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972166, encodeId=944b9e21667b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=119b1409956, createdName=784699923, createdTime=Wed Jun 09 15:52:21 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-10 zsq101

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2016490, encodeId=d5fc201649032, content=<a href='/topic/show?id=6324103414a3' target=_blank style='color:#2F92EE;'>#鼻内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103414, encryptionId=6324103414a3, topicName=鼻内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Mon Aug 23 21:53:47 CST 2021, time=2021-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047418, encodeId=f80e204e4186a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Feb 12 20:53:47 CST 2022, time=2022-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262242, encodeId=2aa71262242cb, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329511, encodeId=a5b81329511bc, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348603, encodeId=bef8134860338, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972520, encodeId=7c979e252038, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/KbC410CniaDHx422zeY8c54ibCJOFj7oBa6J9nvp1TeRiaWuVGbWdu6PUW4bwnfs1umZVdvYU9JLvXuXqf37EdWIQ/132, createdBy=54672480577, createdName=zsq101, createdTime=Thu Jun 10 15:25:18 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972181, encodeId=47e79e218199, content=这样子啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b41d5175461, createdName=学习蜗牛, createdTime=Wed Jun 09 16:35:07 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972166, encodeId=944b9e21667b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=119b1409956, createdName=784699923, createdTime=Wed Jun 09 15:52:21 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-09 学习蜗牛

    这样子啊

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2016490, encodeId=d5fc201649032, content=<a href='/topic/show?id=6324103414a3' target=_blank style='color:#2F92EE;'>#鼻内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103414, encryptionId=6324103414a3, topicName=鼻内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Mon Aug 23 21:53:47 CST 2021, time=2021-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047418, encodeId=f80e204e4186a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Feb 12 20:53:47 CST 2022, time=2022-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262242, encodeId=2aa71262242cb, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329511, encodeId=a5b81329511bc, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348603, encodeId=bef8134860338, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Fri Jun 11 05:53:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972520, encodeId=7c979e252038, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/KbC410CniaDHx422zeY8c54ibCJOFj7oBa6J9nvp1TeRiaWuVGbWdu6PUW4bwnfs1umZVdvYU9JLvXuXqf37EdWIQ/132, createdBy=54672480577, createdName=zsq101, createdTime=Thu Jun 10 15:25:18 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972181, encodeId=47e79e218199, content=这样子啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b41d5175461, createdName=学习蜗牛, createdTime=Wed Jun 09 16:35:07 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972166, encodeId=944b9e21667b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=119b1409956, createdName=784699923, createdTime=Wed Jun 09 15:52:21 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-09 784699923

    学习了

    0

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