JAHA:射血分数正常与射血分数降低的心衰患者再入院、死亡及其相关预测因素

2021-10-21 MedSci原创 MedSci原创

亚洲心衰患者一年心衰再住院率和死亡率很高。该研究确定的结局预测因子有助于风险分层和及时干预。

亚洲心力衰竭(HF)再住院的数据很少。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在通过亚洲心力衰竭心脏猝死(ASIAN-HF)登记中心明确射血分数正常与射血分数降低(EF正常为EF≥50%;EF降低EF<40%)的HF患者的HF(首次和复发)再住院和全因死亡率的负担和预测因素。

研究人员对有症状(C期)慢性HF患者的死亡和复发性HF住院情况进行了1年的随访,并通过Cox回归分析对HF住院或全因死亡率的预测因子进行了评估。

在1666名EF正常的HF患者(平均年龄为68±12岁;50%为女性)和4479名EF降低的HF患者(平均年龄为61±13岁;22%为女性)中,有642人和2302人再次入院,分别有28%和45%归因于HF。在EF正常的HF和EF降低的HF患者中首次HF住院或全因死亡的1年复合事件发生率分别为11%和21%。在EF正常的HF患者中,这些临床终点的一致独立预测因素包括入院患者、东南亚地区以及合并慢性肾病或心房颤动。除了房颤外,相同的变量可预测EF降低的HF患者结局。

由此可见,亚洲心衰患者一年心衰再住院率和死亡率很高。该研究确定的结局预测因子有助于风险分层和及时干预。

原始出处:

Wan Ting Tay.et al.Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021414

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    2021-10-30 houguang2021

    不断学习中

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    2021-10-23 zhaohui6731
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